SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

SIRT1 is a NAD+-dependent deacetylase that governs a number of genetic programs to cope with changes in the nutritional status of cells and organisms. Behavioral responses to food abundance are important for the survival of higher animals. Here we used mice with increased or decreased brain SIRT1 to...

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Bibliographic Details
Main Authors: Pointer, Kelli, Bell, Eric L., Das, Abhirup, Cohen, Dena E., Asara, John M., Kapur, Karen, Bergmann, Sven, Preisig, Martin, Otowa, Takeshi, Kendler, Kenneth S., Chen, Xiangning, Hettema, John M., van den Oord, Edwin J., Rubio, Justin P., Libert, Sergiy V., Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/84481
https://orcid.org/0000-0003-4064-2510

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