Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven unsuccessful. Here, we present a unique mouse model of wild-type EGFR-driven gliom...

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Bibliographic Details
Main Authors: Whittaker, Charles A., Charest, Alain, Acquaviva, Jaime, Jun, Hyun Jung, Lessard, Julie, Ruiz, Rolando, Zhu, Haihao, Donovan, Melissa, Woolfenden, Steve, Boskovitz, Abraham, Raval, Ami, Bronson, Roderick T., Pfannl, Rolf, Housman, David E
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for Cancer Research 2014
Online Access:http://hdl.handle.net/1721.1/84529
https://orcid.org/0000-0001-5016-0756

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