Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type epidermal growth factor receptor (EGFR) and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. Surprisingly, targeted inhibition of EGFR h...

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Bibliographic Details
Main Authors: Jun, Hyun Jung, Acquaviva, Jaime, Chi, D., Lessard, Julie, Zhu, H., Woolfenden, S., Bronson, Roderick T., Pfannl, R., Iyer, L., Boskovitz, Abraham, Raval, A., White, Forest M., Whittaker, Charles A., Charest, Alain, Housman, David E
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/84554
https://orcid.org/0000-0002-1545-1651
https://orcid.org/0000-0001-5016-0756

Internet

http://hdl.handle.net/1721.1/84554
https://orcid.org/0000-0002-1545-1651
https://orcid.org/0000-0001-5016-0756

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