Metastatic Cells Will Take Any Help They Can Get
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metast...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/84580 https://orcid.org/0000-0001-7603-8396 |
| _version_ | 1811095977205956608 |
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| author | Hynes, Richard O |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hynes, Richard O |
| author_sort | Hynes, Richard O |
| collection | MIT |
| description | Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth. |
| first_indexed | 2024-09-23T16:36:21Z |
| format | Article |
| id | mit-1721.1/84580 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:36:21Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/845802022-10-02T08:22:41Z Metastatic Cells Will Take Any Help They Can Get Hynes, Richard O Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Hynes, Richard O. Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis. First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. Second, VCAM-1 allows dormant tumor cells to interact with osteoclasts, yielding paracrine signals and enhancing osteolytic metastatic growth. 2014-01-27T17:14:08Z 2014-01-27T17:14:08Z 2011-12 Article http://purl.org/eprint/type/JournalArticle 15356108 http://hdl.handle.net/1721.1/84580 Hynes, Richard O. “Metastatic Cells Will Take Any Help They Can Get.” Cancer Cell 20, no. 6 (December 2011): 689-690. Copyright © 2011 Elsevier Inc. https://orcid.org/0000-0001-7603-8396 en_US http://dx.doi.org/10.1016/j.ccr.2011.11.022 Cancer Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier Open Archive |
| spellingShingle | Hynes, Richard O Metastatic Cells Will Take Any Help They Can Get |
| title | Metastatic Cells Will Take Any Help They Can Get |
| title_full | Metastatic Cells Will Take Any Help They Can Get |
| title_fullStr | Metastatic Cells Will Take Any Help They Can Get |
| title_full_unstemmed | Metastatic Cells Will Take Any Help They Can Get |
| title_short | Metastatic Cells Will Take Any Help They Can Get |
| title_sort | metastatic cells will take any help they can get |
| url | http://hdl.handle.net/1721.1/84580 https://orcid.org/0000-0001-7603-8396 |
| work_keys_str_mv | AT hynesrichardo metastaticcellswilltakeanyhelptheycanget |