Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides
A new photochemical flow reactor has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly improved both the efficiency and selectivity of the reaction, with the streamlined multi-step...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
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CSIRO Publishing
2014
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| Online Access: | http://hdl.handle.net/1721.1/84603 https://orcid.org/0000-0002-8601-7799 |
| _version_ | 1811088623691366400 |
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| author | Shen, Bo Jamison, Timothy F. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Shen, Bo Jamison, Timothy F. |
| author_sort | Shen, Bo |
| collection | MIT |
| description | A new photochemical flow reactor has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly improved both the efficiency and selectivity of the reaction, with the streamlined multi-step sequence directly furnishing the highly desired unprotected deoxynucleosides. |
| first_indexed | 2024-09-23T14:04:36Z |
| format | Article |
| id | mit-1721.1/84603 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:04:36Z |
| publishDate | 2014 |
| publisher | CSIRO Publishing |
| record_format | dspace |
| spelling | mit-1721.1/846032022-10-01T19:01:57Z Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides Shen, Bo Jamison, Timothy F. Massachusetts Institute of Technology. Department of Chemistry Jamison, Timothy F. Shen, Bo Jamison, Timothy F. A new photochemical flow reactor has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′,3′-dideoxynucleosides. The continuous flow format significantly improved both the efficiency and selectivity of the reaction, with the streamlined multi-step sequence directly furnishing the highly desired unprotected deoxynucleosides. Novartis-MIT Center for Continuous Manufacturing 2014-01-27T20:00:03Z 2014-01-27T20:00:03Z 2013-11 2012-09 Article http://purl.org/eprint/type/JournalArticle 0004-9425 http://hdl.handle.net/1721.1/84603 Shen, Bo, and Timothy F. Jamison. “Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides.” Australian Journal of Chemistry 66, no. 2 (2013): 157. https://orcid.org/0000-0002-8601-7799 en_US http://dx.doi.org/10.1071/ch12426 Australian Journal of Chemistry Creative Commons Attribution-Noncommercial-Share Alike 3.0 http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf CSIRO Publishing Prof. Jamison via Erja Kajosalo |
| spellingShingle | Shen, Bo Jamison, Timothy F. Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides |
| title | Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides |
| title_full | Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides |
| title_fullStr | Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides |
| title_full_unstemmed | Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides |
| title_short | Continuous Flow Photochemistry for the Rapid and Selective Synthesis of 2'-Deoxy and 2',3'-Dideoxynucleosides |
| title_sort | continuous flow photochemistry for the rapid and selective synthesis of 2 deoxy and 2 3 dideoxynucleosides |
| url | http://hdl.handle.net/1721.1/84603 https://orcid.org/0000-0002-8601-7799 |
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