Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm
This year’s Nobel Prize in Physiology or Medicine was awarded to John Gurdon and Shinya Yamanaka for solving key problems of biology. Their work provided fundamental insights into how an egg gives rise to a complex organism consisting of many different cell types and has transformed our understandin...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/84640 |
| _version_ | 1826209603347546112 |
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| author | Jaenisch, Rudolf |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Jaenisch, Rudolf |
| author_sort | Jaenisch, Rudolf |
| collection | MIT |
| description | This year’s Nobel Prize in Physiology or Medicine was awarded to John Gurdon and Shinya Yamanaka for solving key problems of biology. Their work provided fundamental insights into how an egg gives rise to a complex organism consisting of many different cell types and has transformed our understanding of nuclear reprogramming, of embryonic development, and of cellular differentiation. These are issues that have a long history and the reader is referred to a comprehensive review by Graf (2011) on cellular plasticity and a summary of current issues of the reprogramming field by Yamanaka (2012). Here I will give a personal view on how the discoveries of Gurdon and Yamanaka have shaped our understanding of basic mechanisms of development and how stem cells will revolutionize the way we investigate human disease and establish novel treatment strategies. |
| first_indexed | 2024-09-23T14:25:05Z |
| format | Article |
| id | mit-1721.1/84640 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:25:05Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/846402022-10-01T21:14:21Z Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm Jaenisch, Rudolf Massachusetts Institute of Technology. Department of Biology Jaenisch, Rudolf This year’s Nobel Prize in Physiology or Medicine was awarded to John Gurdon and Shinya Yamanaka for solving key problems of biology. Their work provided fundamental insights into how an egg gives rise to a complex organism consisting of many different cell types and has transformed our understanding of nuclear reprogramming, of embryonic development, and of cellular differentiation. These are issues that have a long history and the reader is referred to a comprehensive review by Graf (2011) on cellular plasticity and a summary of current issues of the reprogramming field by Yamanaka (2012). Here I will give a personal view on how the discoveries of Gurdon and Yamanaka have shaped our understanding of basic mechanisms of development and how stem cells will revolutionize the way we investigate human disease and establish novel treatment strategies. 2014-02-03T14:24:34Z 2014-02-03T14:24:34Z 2012-12 Article http://purl.org/eprint/type/JournalArticle 19345909 http://hdl.handle.net/1721.1/84640 Jaenisch, Rudolf. “Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm.” Cell Stem Cell 11, no. 6 (December 2012): 744-747. Copyright © 2012 Elsevier Inc. en_US http://dx.doi.org/10.1016/j.stem.2012.11.005 Cell Stem Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier Open Archive |
| spellingShingle | Jaenisch, Rudolf Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm |
| title | Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm |
| title_full | Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm |
| title_fullStr | Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm |
| title_full_unstemmed | Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm |
| title_short | Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm |
| title_sort | nuclear cloning and direct reprogramming the long and the short path to stockholm |
| url | http://hdl.handle.net/1721.1/84640 |
| work_keys_str_mv | AT jaenischrudolf nuclearcloninganddirectreprogrammingthelongandtheshortpathtostockholm |