Complete deletion of Apc results in severe polyposis in mice

Complete deletion of Apc results in severe polyposis in mice

The adenomatous polyposis coli (APC) gene product is mutated in the vast majority of human colorectal cancers. APC negatively regulates the WNT pathway by aiding in the degradation of β-catenin, which is the transcription factor activated downstream of WNT signaling. APC mutations result in β-cateni...

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Bibliographic Details
Main Authors:	Bronson, Roderick T., Haigis, Kevin M., Cheung, Ann, Carter, Alia, Kostova, Kamena K., Woodruff, Joe, Crowley, Denise G., Jacks, Tyler E
Other Authors:	Koch Institute for Integrative Cancer Research at MIT
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2014
Online Access:	http://hdl.handle.net/1721.1/84641 https://orcid.org/0000-0001-5785-8911

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