HIF-2α deletion promotes Kras-driven lung tumor development

HIF-2α deletion promotes Kras-driven lung tumor development

Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. The oxygen-sensitive hypoxia inducible factor (HIF) transcriptional regulators HIF-1α and HIF-2α are overexpressed in many human NSCLCs, and constitutive HIF-2α activity can promote murine lung tumor progression, sug...

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Bibliographic Details
Main Authors: Mazumdar, Jolly, Hickey, Michele M., Pant, Dhruv K., Durham, Amy C., Sweet-Cordero, Alejandro, Vachani, Anil, Chodosh, Lewis A., Kissil, Joseph L., Simon, M. Celeste, Keith, Brian, Jacks, Tyler E
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/84643
https://orcid.org/0000-0001-5785-8911

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