SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

Background: The somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood. Methods: We obtained DNA samples from leukemia cells in 91 patients with chronic lymphocytic leukemia and performed massively paral...

Full description

Bibliographic Details
Main Authors:	Wang, Lili, Lawrence, Michael S., Wan, Youzhong, Stojanov, Petar, Sougnez, Carrie, Stevenson, Kristen, Werner, Lillian, Sivachenko, Andrey, DeLuca, David S., Zhang, Li, Zhang, Wandi, Vartanov, Alexander R., Fernandes, Stacey M., Goldstein, Natalie R., Folco, Eric G., Cibulskis, Kristian, Tesar, Bethany, Sievers, Quinlan L., Shefler, Erica, Gabriel, Stacey B., Hacohen, Nir, Reed, Robin, Meyerson, Matthew L., Golub, Todd R., Neuberg, Donna S., Brown, Jennifer R., Getz, Gad, Wu, Catherine J., Lander, Eric S., Lander, Eric Steven
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	New England Journal of Medicine 2014
Online Access:	http://hdl.handle.net/1721.1/84659

Similar Items

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
by: Landau, Dan A., et al.
Published: (2014)

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
by: Cibulskis, Kristian, et al.
Published: (2014)

Discovery and saturation analysis of cancer genes across 21 tumour types
by: Lawrence, Michael S., et al.
Published: (2015)

Comprehensive molecular characterization of gastric adenocarcinoma
by: Getz, Gad Asher, et al.
Published: (2018)

Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
by: Lander, Eric S., et al.
Published: (2012)

Integrated genomic analyses of ovarian carcinoma
by: Meyerson, Matthew L., et al.
Published: (2012)

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability
by: Drier, Yotam, et al.
Published: (2013)

Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia
by: Landau, Dan A., et al.
Published: (2017)

Defining the core essential genome of Pseudomonas aeruginosa
by: Lander, Eric S.
Published: (2020)

Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data
by: Lander, Eric S.
Published: (2020)

Distinct gene-set burden patterns underlie common generalized and focal epilepsies
by: Lander, Eric
Published: (2022)

Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia
by: Zekavat, Seyedeh M., et al.
Published: (2020)

Positional specificity of different transcription factor classes within enhancers
by: Engreitz, Jesse, et al.
Published: (2019)

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
by: Lander, Eric Steven
Published: (2013)

Mutations driving CLL and their evolution in progression and relapse
by: Lander, Eric Steven
Published: (2017)

Inherited causes of clonal haematopoiesis in 97,691 whole genomes
by: Lander, Eric Steven
Published: (2022)

The genome of the green anole lizard and a comparative analysis with birds and mammals
by: Lander, Eric Steven
Published: (2012)

A polygenic burden of rare disruptive mutations in schizophrenia
by: Lander, Eric Steven
Published: (2015)

Comprehensive molecular characterization of human colon and rectal cancer
by: Lander, Eric Steven
Published: (2014)

The landscape of somatic copy-number alteration across human cancers
by: Lander, Eric Steven
Published: (2012)

Comprehensive molecular profiling of lung adenocarcinoma
by: Lander, Eric Steven
Published: (2015)

The genomic basis of adaptive evolution in threespine sticklebacks
by: Lander, Eric Steven
Published: (2012)

A structural variation reference for medical and population genetics
by: Lander, Eric Steven
Published: (2022)

The genetic landscape of high-risk neuroblastoma
by: Lander, Eric Steven
Published: (2014)

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition
by: Lander, Eric Steven
Published: (2017)

The genomic substrate for adaptive radiation in African cichlid fish
by: Lander, Eric Steven
Published: (2015)

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
by: Lander, Eric Steven
Published: (2017)

Whole-exome sequencing and clinical interpretation of FFPE tumor samples to guide precision cancer medicine
by: Lander, Eric Steven
Published: (2015)

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
by: Lander, Eric Steven
Published: (2014)

Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication
by: Lander, Eric Steven
Published: (2015)

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
by: Lander, Eric Steven
Published: (2017)

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
by: Lander, Eric Steven
Published: (2015)

Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease
by: Lander, Eric Steven
Published: (2015)

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
by: Lander, Eric Steven
Published: (2012)

Punctuated Evolution of Prostate Cancer Genomes
by: Lander, Eric Steven
Published: (2016)

Brave New Genome
by: Lander, Eric Steven
Published: (2017)

The mystery of missing heritability: Genetic interactions create phantom heritability
by: Sunyaev, Shamil R., et al.
Published: (2012)

Integrative analysis of the melanoma transcriptome
by: Berger, Michael F., et al.
Published: (2012)

Comprehensive assessment of cancer missense mutation clustering in protein structures
by: Kamburov, Atanas, et al.
Published: (2018)

Deconstructing categories syncretic with the nominal complementizer
by: Eric Lander, et al.
Published: (2018-03-01)