Polarity and cell fate asymmetry in Caulobacter crescentus
The production of asymmetric daughter cells is a hallmark of metazoan development and critical to the life cycle of many microbes, including the α-proteobacterium Caulobacter crescentus. For Caulobacter, every cell division is asymmetric, yielding daughter cells with different morphologies and repli...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/84665 https://orcid.org/0000-0002-8288-7607 |
| _version_ | 1811096662405283840 |
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| author | Tsokos, Christos G. Laub, Michael T |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Tsokos, Christos G. Laub, Michael T |
| author_sort | Tsokos, Christos G. |
| collection | MIT |
| description | The production of asymmetric daughter cells is a hallmark of metazoan development and critical to the life cycle of many microbes, including the α-proteobacterium Caulobacter crescentus. For Caulobacter, every cell division is asymmetric, yielding daughter cells with different morphologies and replicative potentials. This asymmetry in daughter cell fate is governed by the response regulator CtrA, a transcription factor that can also bind and silence the origin of replication. CtrA activity is controlled by a complex regulatory circuit that includes several polarly localized histidine kinases. This circuit ensures differential activation of CtrA in daughter cells, leading to their asymmetric replicative potentials. Here, we review progress in elucidating the molecular mechanisms regulating CtrA and the role of cellular polarity in this process. |
| first_indexed | 2024-09-23T16:47:02Z |
| format | Article |
| id | mit-1721.1/84665 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:47:02Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/846652022-09-29T21:28:21Z Polarity and cell fate asymmetry in Caulobacter crescentus Tsokos, Christos G. Laub, Michael T Massachusetts Institute of Technology. Department of Biology Tsokos, Christos G. Laub, Michael T. The production of asymmetric daughter cells is a hallmark of metazoan development and critical to the life cycle of many microbes, including the α-proteobacterium Caulobacter crescentus. For Caulobacter, every cell division is asymmetric, yielding daughter cells with different morphologies and replicative potentials. This asymmetry in daughter cell fate is governed by the response regulator CtrA, a transcription factor that can also bind and silence the origin of replication. CtrA activity is controlled by a complex regulatory circuit that includes several polarly localized histidine kinases. This circuit ensures differential activation of CtrA in daughter cells, leading to their asymmetric replicative potentials. Here, we review progress in elucidating the molecular mechanisms regulating CtrA and the role of cellular polarity in this process. National Institutes of Health (U.S.) (Grant 5R01GM082899) 2014-02-07T13:59:17Z 2014-02-07T13:59:17Z 2012-11 Article http://purl.org/eprint/type/JournalArticle 13695274 http://hdl.handle.net/1721.1/84665 Tsokos, Christos G, and Michael T Laub. “Polarity and cell fate asymmetry in Caulobacter crescentus.” Current Opinion in Microbiology 15, no. 6 (December 2012): 744-750. https://orcid.org/0000-0002-8288-7607 en_US http://dx.doi.org/10.1016/j.mib.2012.10.011 Current Opinion in Microbiology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Tsokos, Christos G. Laub, Michael T Polarity and cell fate asymmetry in Caulobacter crescentus |
| title | Polarity and cell fate asymmetry in Caulobacter crescentus |
| title_full | Polarity and cell fate asymmetry in Caulobacter crescentus |
| title_fullStr | Polarity and cell fate asymmetry in Caulobacter crescentus |
| title_full_unstemmed | Polarity and cell fate asymmetry in Caulobacter crescentus |
| title_short | Polarity and cell fate asymmetry in Caulobacter crescentus |
| title_sort | polarity and cell fate asymmetry in caulobacter crescentus |
| url | http://hdl.handle.net/1721.1/84665 https://orcid.org/0000-0002-8288-7607 |
| work_keys_str_mv | AT tsokoschristosg polarityandcellfateasymmetryincaulobactercrescentus AT laubmichaelt polarityandcellfateasymmetryincaulobactercrescentus |