Evolving a robust signal transduction pathway from weak cross-talk

Evolving a robust signal transduction pathway from weak cross-talk

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We have evolved a robust two‐component signal transduction pathway from a sensor kinase (SK) and non‐partner response regulator (RR) that show weak cross‐talk in vitro and no detectable cross‐talk in vivo in wild‐type strains. The SK, CpxA, is bifunctional, with both kinase and phosphatase activitie...

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Bibliographic Details
Main Authors:	Siryaporn, Albert, Goulian, Mark, Perchuk, Barrett, Laub, Michael T
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2014
Online Access:	http://hdl.handle.net/1721.1/84667 https://orcid.org/0000-0002-8288-7607

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