Chromosome Segregation: Keeping Kinetochores in the Loop

The Ndc80 complex is a key component of the kinetochore–microtubule interface. Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 plays an unexpected role in recruiting proteins to the kinetochore.

Bibliographic Details
Main Authors: Schmidt, Jens Christopher, Cheeseman, Iain M
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier B.V. 2014
Online Access:http://hdl.handle.net/1721.1/84677
https://orcid.org/0000-0002-3829-5612
Description
Summary:The Ndc80 complex is a key component of the kinetochore–microtubule interface. Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 plays an unexpected role in recruiting proteins to the kinetochore.