The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B

The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B

Modulation of alternative pre-mRNA splicing is a potential approach to therapeutic targeting for a variety of human diseases. We investigated the mechanism by which digitoxin, a member of the cardiotonic steroid class of drugs, regulates alternative splicing. Transcriptome-wide analysis identified a...

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Bibliographic Details
Main Authors:	Anderson, Erik S., Lin, Chia-Ho, Xiao, Xinshu, Stoilov, Peter, Black, Douglas L., Burge, Christopher B
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Cold Spring Harbor Laboratory Press 2014
Online Access:	http://hdl.handle.net/1721.1/84678

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