From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones
This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitor...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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John Wiley & Sons, Inc
2014
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| Online Access: | http://hdl.handle.net/1721.1/84708 https://orcid.org/0000-0002-7029-7415 |
| _version_ | 1826209034228727808 |
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| author | Flygare, Johan Chou, Song Lodish, Harvey F |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Flygare, Johan Chou, Song Lodish, Harvey F |
| author_sort | Flygare, Johan |
| collection | MIT |
| description | This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages. |
| first_indexed | 2024-09-23T14:16:37Z |
| format | Article |
| id | mit-1721.1/84708 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:16:37Z |
| publishDate | 2014 |
| publisher | John Wiley & Sons, Inc |
| record_format | dspace |
| spelling | mit-1721.1/847082022-10-01T20:15:59Z From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones Flygare, Johan Chou, Song Lodish, Harvey F Massachusetts Institute of Technology. Department of Biology Lodish, Harvey F. Flygare, Johan Chou, Song This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages. National Institutes of Health (U.S.) (grant P01 HL 32262) National Institutes of Health (U.S.) (grant DK06735) Amgen Inc. Swedish Research Council Maja och Hjalmar Leanders Stiftelse National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award Sweden-America Foundation 2014-02-07T20:40:04Z 2014-02-07T20:40:04Z 2010-03 2010-02 Article http://purl.org/eprint/type/JournalArticle 15216543 15216551 http://hdl.handle.net/1721.1/84708 Lodish, Harvey, Johan Flygare, and Song Chou. “From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones.” IUBMB Life 62, no. 7 (July 19, 2010): 492-496. https://orcid.org/0000-0002-7029-7415 en_US http://dx.doi.org/10.1002/iub.322 IUBMB Life Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf John Wiley & Sons, Inc PMC |
| spellingShingle | Flygare, Johan Chou, Song Lodish, Harvey F From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones |
| title | From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones |
| title_full | From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones |
| title_fullStr | From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones |
| title_full_unstemmed | From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones |
| title_short | From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones |
| title_sort | from stem cell to erythroblast regulation of red cell production at multiple levels by multiple hormones |
| url | http://hdl.handle.net/1721.1/84708 https://orcid.org/0000-0002-7029-7415 |
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