Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins

Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display of influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA). The...

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Bibliographic Details
Main Authors: Ploegh, Hidde, Tafesse, Fikadu G., Sanyal, Sumana, Ashour, Joseph, Guimaraes, Carla P., Hermansson, Martin, Somerharju, Pentti
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/84947
https://orcid.org/0000-0002-1090-6071

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