Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation
How can species remain unaltered for long periods yet also undergo rapid diversification? By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 protein-folding reservoir might promote both stasis and change. However, the nature and adaptive value of Hsp90-contingen...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2014
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| Online Access: | http://hdl.handle.net/1721.1/84954 https://orcid.org/0000-0003-1307-882X |
| _version_ | 1811094532285005824 |
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| author | Jarosz, Daniel F. Lindquist, Susan |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Jarosz, Daniel F. Lindquist, Susan |
| author_sort | Jarosz, Daniel F. |
| collection | MIT |
| description | How can species remain unaltered for long periods yet also undergo rapid diversification? By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 protein-folding reservoir might promote both stasis and change. However, the nature and adaptive value of Hsp90-contingent traits remain uncertain. In ecologically and genetically diverse yeasts, we find such traits to be both common and frequently adaptive. Most are based on preexisting variation, with causative polymorphisms occurring in coding and regulatory sequences alike. A common temperature stress alters phenotypes similarly. Both selective inhibition of Hsp90 and temperature stress increase correlations between genotype and phenotype. This system broadly determines the adaptive value of standing genetic variation and, in so doing, has influenced the evolution of current genomes. |
| first_indexed | 2024-09-23T16:01:40Z |
| format | Article |
| id | mit-1721.1/84954 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:01:40Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/849542022-09-29T17:43:51Z Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation Jarosz, Daniel F. Lindquist, Susan Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Jarosz, Daniel F. Lindquist, Susan How can species remain unaltered for long periods yet also undergo rapid diversification? By linking genetic variation to phenotypic variation via environmental stress, the Hsp90 protein-folding reservoir might promote both stasis and change. However, the nature and adaptive value of Hsp90-contingent traits remain uncertain. In ecologically and genetically diverse yeasts, we find such traits to be both common and frequently adaptive. Most are based on preexisting variation, with causative polymorphisms occurring in coding and regulatory sequences alike. A common temperature stress alters phenotypes similarly. Both selective inhibition of Hsp90 and temperature stress increase correlations between genotype and phenotype. This system broadly determines the adaptive value of standing genetic variation and, in so doing, has influenced the evolution of current genomes. Broad Institute of MIT and Harvard G. Harold and Leila Y. Mathers Foundation Howard Hughes Medical Institute Howard Hughes Medical Institute (Investigator) Damon Runyon Cancer Research Foundation (HHMI fellow, DRG-1964-08) 2014-02-14T17:03:08Z 2014-02-14T17:03:08Z 2010-12 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/84954 Jarosz, D. F., and S. Lindquist. “Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation.” Science 330, no. 6012 (December 23, 2010): 1820-1824. https://orcid.org/0000-0003-1307-882X en_US http://dx.doi.org/10.1126/science.1195487 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Jarosz, Daniel F. Lindquist, Susan Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation |
| title | Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation |
| title_full | Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation |
| title_fullStr | Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation |
| title_full_unstemmed | Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation |
| title_short | Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation |
| title_sort | hsp90 and environmental stress transform the adaptive value of natural genetic variation |
| url | http://hdl.handle.net/1721.1/84954 https://orcid.org/0000-0003-1307-882X |
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