Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection
Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely extensively on host machinery for replication; therefore, it is not surprising that viruses connect to the ubiquitin pathway at many levels. Viral involvement with ubiquitin occurs either adventitiously because o...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/84989 https://orcid.org/0000-0002-1090-6071 |
| _version_ | 1811077234246549504 |
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| author | Isaacson, Marisa K. Ploegh, Hidde |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Isaacson, Marisa K. Ploegh, Hidde |
| author_sort | Isaacson, Marisa K. |
| collection | MIT |
| description | Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely extensively on host machinery for replication; therefore, it is not surprising that viruses connect to the ubiquitin pathway at many levels. Viral involvement with ubiquitin occurs either adventitiously because of the unavoidable usurpation of cellular processes, or for some specific purpose selected for by the virus to enhance viral replication. Here, we review current knowledge of how the ubiquitin pathway alters viral replication and how viruses influence the ubiquitin pathway to enhance their own replication. |
| first_indexed | 2024-09-23T10:39:47Z |
| format | Article |
| id | mit-1721.1/84989 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:39:47Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/849892022-09-30T22:06:26Z Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection Isaacson, Marisa K. Ploegh, Hidde Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Ploegh, Hidde Ubiquitin is important for nearly every aspect of cellular physiology. All viruses rely extensively on host machinery for replication; therefore, it is not surprising that viruses connect to the ubiquitin pathway at many levels. Viral involvement with ubiquitin occurs either adventitiously because of the unavoidable usurpation of cellular processes, or for some specific purpose selected for by the virus to enhance viral replication. Here, we review current knowledge of how the ubiquitin pathway alters viral replication and how viruses influence the ubiquitin pathway to enhance their own replication. 2014-02-18T20:10:27Z 2014-02-18T20:10:27Z 2009-06 Article http://purl.org/eprint/type/JournalArticle 19313128 http://hdl.handle.net/1721.1/84989 Isaacson, Marisa K., and Hidde L. Ploegh. “Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection.” Cell Host & Microbe 5, no. 6 (June 2009): 559-570. Copyright © 2009 Elsevier Inc. https://orcid.org/0000-0002-1090-6071 en_US http://dx.doi.org/10.1016/j.chom.2009.05.012 Cell Host & Microbe Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier Open Archive |
| spellingShingle | Isaacson, Marisa K. Ploegh, Hidde Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection |
| title | Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection |
| title_full | Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection |
| title_fullStr | Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection |
| title_full_unstemmed | Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection |
| title_short | Ubiquitination, Ubiquitin-like Modifiers, and Deubiquitination in Viral Infection |
| title_sort | ubiquitination ubiquitin like modifiers and deubiquitination in viral infection |
| url | http://hdl.handle.net/1721.1/84989 https://orcid.org/0000-0002-1090-6071 |
| work_keys_str_mv | AT isaacsonmarisak ubiquitinationubiquitinlikemodifiersanddeubiquitinationinviralinfection AT ploeghhidde ubiquitinationubiquitinlikemodifiersanddeubiquitinationinviralinfection |