Strategies to discover regulatory circuits of the mammalian immune system
Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools ef...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/84993 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826216095537692672 |
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| author | Amit, Ido Regev, Aviv Hacohen, Nir |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Amit, Ido Regev, Aviv Hacohen, Nir |
| author_sort | Amit, Ido |
| collection | MIT |
| description | Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools effectively. One application with great potential to enhance our understanding of biological systems is the unbiased reconstruction of genetic and molecular networks. Cells of the immune system provide a particularly useful model for developing and applying such approaches. Here, we review approaches for the reconstruction of signalling and transcriptional networks, with a focus on applications in the mammalian innate immune system. |
| first_indexed | 2024-09-23T16:42:15Z |
| format | Article |
| id | mit-1721.1/84993 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:42:15Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/849932022-09-29T20:52:18Z Strategies to discover regulatory circuits of the mammalian immune system Amit, Ido Regev, Aviv Hacohen, Nir Massachusetts Institute of Technology. Department of Biology Regev, Aviv Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools effectively. One application with great potential to enhance our understanding of biological systems is the unbiased reconstruction of genetic and molecular networks. Cells of the immune system provide a particularly useful model for developing and applying such approaches. Here, we review approaches for the reconstruction of signalling and transcriptional networks, with a focus on applications in the mammalian innate immune system. National Institutes of Health (U.S.) Howard Hughes Medical Institute Broad Institute of MIT and Harvard 2014-02-18T20:49:59Z 2014-02-18T20:49:59Z 2011-11 Article http://purl.org/eprint/type/JournalArticle 1474-1733 1474-1741 http://hdl.handle.net/1721.1/84993 Amit, Ido, Aviv Regev, and Nir Hacohen. “Strategies to discover regulatory circuits of the mammalian immune system.” Nature Reviews Immunology (November 18, 2011). https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1038/nri3109 Nature Reviews Immunology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Amit, Ido Regev, Aviv Hacohen, Nir Strategies to discover regulatory circuits of the mammalian immune system |
| title | Strategies to discover regulatory circuits of the mammalian immune system |
| title_full | Strategies to discover regulatory circuits of the mammalian immune system |
| title_fullStr | Strategies to discover regulatory circuits of the mammalian immune system |
| title_full_unstemmed | Strategies to discover regulatory circuits of the mammalian immune system |
| title_short | Strategies to discover regulatory circuits of the mammalian immune system |
| title_sort | strategies to discover regulatory circuits of the mammalian immune system |
| url | http://hdl.handle.net/1721.1/84993 https://orcid.org/0000-0001-8567-2049 |
| work_keys_str_mv | AT amitido strategiestodiscoverregulatorycircuitsofthemammalianimmunesystem AT regevaviv strategiestodiscoverregulatorycircuitsofthemammalianimmunesystem AT hacohennir strategiestodiscoverregulatorycircuitsofthemammalianimmunesystem |