Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
PMC 2012 November 01
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/85068 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826205027979493376 |
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| author | Narayan, Kavitha Sylvia, Katelyn E. Malhotra, Nidhi Yin, Catherine C. Martens, Gregory Vallerskog, Therese Kornfeld, Hardy Xiong, Na Cohen, Nadia R. Brenner, Michael B. Berg, Leslie J. Kang, Joonsoo Immunological Genome Project Consortium Regev, Aviv |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Narayan, Kavitha Sylvia, Katelyn E. Malhotra, Nidhi Yin, Catherine C. Martens, Gregory Vallerskog, Therese Kornfeld, Hardy Xiong, Na Cohen, Nadia R. Brenner, Michael B. Berg, Leslie J. Kang, Joonsoo Immunological Genome Project Consortium Regev, Aviv |
| author_sort | Narayan, Kavitha |
| collection | MIT |
| description | PMC 2012 November 01 |
| first_indexed | 2024-09-23T13:05:55Z |
| format | Article |
| id | mit-1721.1/85068 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:05:55Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/850682022-09-28T11:58:24Z Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes Narayan, Kavitha Sylvia, Katelyn E. Malhotra, Nidhi Yin, Catherine C. Martens, Gregory Vallerskog, Therese Kornfeld, Hardy Xiong, Na Cohen, Nadia R. Brenner, Michael B. Berg, Leslie J. Kang, Joonsoo Immunological Genome Project Consortium Regev, Aviv Massachusetts Institute of Technology. Department of Biology Regev, Aviv PMC 2012 November 01 Innate γδ T cells function in the early phase of immune responses. Although innate γδ T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, γδ effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of γδ effector cells. A high-resolution transcriptome analysis of all emergent γδ thymocyte subsets segregated on the basis of use of the TCR γ-chain or δ-chain indicated the existence of three separate subtypes of γδ effector cells in the thymus. The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function. National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Diabetes and Endocrinology Research Center, DK32520) National Institutes of Health (U.S.) (R24 AI072073 to the ImmGen group) National Institutes of Health (U.S.) (CA100382) National Institute of Allergy and Infectious Diseases (U.S.) 2014-02-21T18:20:11Z 2014-02-21T18:20:11Z 2012-04 Article http://purl.org/eprint/type/JournalArticle 1529-2908 1529-2916 http://hdl.handle.net/1721.1/85068 Narayan, Kavitha, Katelyn E Sylvia, Nidhi Malhotra, Catherine C Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, et al. “Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes.” Nature Immunology 13, no. 5 (April 1, 2012): 511-518. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1038/ni.2247 Nature Immunology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Narayan, Kavitha Sylvia, Katelyn E. Malhotra, Nidhi Yin, Catherine C. Martens, Gregory Vallerskog, Therese Kornfeld, Hardy Xiong, Na Cohen, Nadia R. Brenner, Michael B. Berg, Leslie J. Kang, Joonsoo Immunological Genome Project Consortium Regev, Aviv Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes |
| title | Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes |
| title_full | Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes |
| title_fullStr | Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes |
| title_full_unstemmed | Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes |
| title_short | Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes |
| title_sort | intrathymic programming of effector fates in three molecularly distinct γδ t cell subtypes |
| url | http://hdl.handle.net/1721.1/85068 https://orcid.org/0000-0001-8567-2049 |
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