DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization

Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the p38/MK2 pathway for survival after DNA damage, despite a functional ATR-Chk1 pa...

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Bibliographic Details
Main Authors: Reinhardt, H. Christian, Hasskamp, Pia, Schmedding, Ingolf, Morandell, Sandra, van Vugt, Marcel A.T.M., Wang, XiaoZhe, Linding, Rune, Ong, Shao-En, Weaver, David, Carr, Steven A., Yaffe, Michael B
Other Authors: Massachusetts Institute of Technology. Cell Decision Process Center
Format: Article
Language:en_US
Published: Elsevier B.V. 2014
Online Access:http://hdl.handle.net/1721.1/85107
https://orcid.org/0000-0002-9547-3251

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