PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and Aβ

PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and Aβ

Defects in p21-activated kinase (PAK) are suspected to play a role in cognitive symptoms of Alzheimer's disease (AD). Dysfunction in PAK leads to cofilin activation, drebrin displacement from its actin-binding site, actin depolymerization/severing, and, ultimately, defects in spine dynamics and...

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Bibliographic Details
Main Authors:	Tonegawa, Susumu, Arsenault, Dany, Dal-Pan, Alexandre, Tremblay, Cyntia, Bennett, David A., Guitton, Matthieu J., De Koninck, Yves, Calon, Frederic
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Society for Neuroscience 2014
Online Access:	http://hdl.handle.net/1721.1/85179 https://orcid.org/0000-0003-2839-8228

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