Unbiased reconstruction of a mammalian transcriptional network mediating the differential response to pathogens

Unbiased reconstruction of a mammalian transcriptional network mediating the differential response to pathogens

Models of mammalian regulatory networks controlling gene expression have been inferred from genomic data but have largely not been validated. We present an unbiased strategy to systematically perturb candidate regulators and monitor cellular transcriptional responses. We applied this approach to der...

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ग्रंथसूची विवरण
मुख्य लेखकों: Amit, Ido, Guttman, Mitchell, Leite, Ana Paula, Regev, Aviv, Garber, Manuel, Chevrier, Nicolas, Donner, Yoni, Eisenhaure, Thomas, Grenier, Jennifer K., Li, Weibo, Zuk, Or, Schubert, Lisa A., Birditt, Brian, Shay, Tal, Goren, Alon, Zhang, Xiaolan, Smith, Zachary, Deering, Raquel, McDonald, Rebecca C., Cabili, Moran N., Bernstein, Bradley E., Rinn, John L., Meissner, Alexander, Root, David E., Hacohen, Nir
अन्य लेखक: Massachusetts Institute of Technology. Computational and Systems Biology Program
स्वरूप: लेख
भाषा:en_US
प्रकाशित: American Association for the Advancement of Science (AAAS) 2014
ऑनलाइन पहुंच:http://hdl.handle.net/1721.1/85204
https://orcid.org/0000-0001-5773-3211
https://orcid.org/0000-0001-8567-2049

इंटरनेट

http://hdl.handle.net/1721.1/85204
https://orcid.org/0000-0001-5773-3211
https://orcid.org/0000-0001-8567-2049

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