Generative probabilistic models of neuron morphology
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2014
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| Online Access: | http://hdl.handle.net/1721.1/85494 |
| _version_ | 1826200299153391616 |
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| author | Serene, Stephen Rothrock |
| author2 | Joshua Tenenbaum. |
| author_facet | Joshua Tenenbaum. Serene, Stephen Rothrock |
| author_sort | Serene, Stephen Rothrock |
| collection | MIT |
| description | Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013. |
| first_indexed | 2024-09-23T11:34:21Z |
| format | Thesis |
| id | mit-1721.1/85494 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:34:21Z |
| publishDate | 2014 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/854942019-04-12T20:41:46Z Generative probabilistic models of neuron morphology Serene, Stephen Rothrock Joshua Tenenbaum. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013. Cataloged from PDF version of thesis. Includes bibliographical references (page 40). Thanks to automation in ultrathin sectioning and confocal and electron microscopy, it is now possible to image large populations of neurons at single-cell resolution. This imaging capability promises to create a new field of neural circuit microanatomy. Three goals of such a field would be to trace multi-cell neural networks, to classify neurons into morphological cell types, and to compare patterns and statistics of connectivity in large networks to meaningful null models. However, those goals raise significant computational challenges. In particular, since neural morphology spans six orders of magnitude in length (roughly 1 nm-1 mm), a spatial hierarchy of representations is needed to capture micron-scale morphological features in nanometer resolution images. For this thesis, I have built and characterized a system that learns such a representation as a Multivariate Hidden Markov Model over skeletonized neurons. I have developed and implemented a maximum likelihood method for learning an HMM over a directed, unrooted tree structure of arbitrary degree. In addition, I have developed and implemented a set of object-oriented data structures to support this HMM, and to produce a directed tree given a division of the leaf nodes into inputs and outputs. Furthermore, I have developed a set of features on which to train the HMM based only on information in the skeletonized neuron, and I have tested this system on a dataset consisting of confocal microscope images of 14 fluorescence-labeled mouse retinal ganglion cells. Additionally, I have developed a system to simulate neurons of varying difficulty for the HMM, and analyzed its performance on those neurons. Finally, I have explored whether the HMMs this system learns could successfully detect errors in simulated and, eventually, neural datasets. by Stephen Rothrock Serene. M. Eng. 2014-03-06T15:46:03Z 2014-03-06T15:46:03Z 2013 2013 Thesis http://hdl.handle.net/1721.1/85494 870999352 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 40 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Serene, Stephen Rothrock Generative probabilistic models of neuron morphology |
| title | Generative probabilistic models of neuron morphology |
| title_full | Generative probabilistic models of neuron morphology |
| title_fullStr | Generative probabilistic models of neuron morphology |
| title_full_unstemmed | Generative probabilistic models of neuron morphology |
| title_short | Generative probabilistic models of neuron morphology |
| title_sort | generative probabilistic models of neuron morphology |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/85494 |
| work_keys_str_mv | AT serenestephenrothrock generativeprobabilisticmodelsofneuronmorphology |