MicroRNA Functions in Stress Responses
MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier B.V.
2014
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| Online Access: | http://hdl.handle.net/1721.1/85552 https://orcid.org/0000-0003-1465-1691 |
| _version_ | 1826201155670114304 |
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| author | Leung, Anthony Sharp, Phillip A. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Leung, Anthony Sharp, Phillip A. |
| author_sort | Leung, Anthony |
| collection | MIT |
| description | MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing, and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers. |
| first_indexed | 2024-09-23T11:47:24Z |
| format | Article |
| id | mit-1721.1/85552 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:47:24Z |
| publishDate | 2014 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/855522022-09-27T21:53:55Z MicroRNA Functions in Stress Responses Leung, Anthony Sharp, Phillip A. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Leung, Anthony Sharp, Phillip A. MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing, and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers. National Institutes of Health (U.S.) (RO1-CA133404) National Cancer Institute (U.S.) (PO1-CA42063) National Cancer Institute (U.S.) (Cancer Center Support (core) grant P30-CA14051) Leukemia & Lymphoma Society of America (special fellow) 2014-03-06T21:05:46Z 2014-03-06T21:05:46Z 2010-10 Article http://purl.org/eprint/type/JournalArticle 10972765 http://hdl.handle.net/1721.1/85552 Leung, Anthony K.L., and Phillip A. Sharp. “MicroRNA Functions in Stress Responses.” Molecular Cell 40, no. 2 (October 2010): 205-215. https://orcid.org/0000-0003-1465-1691 en_US http://dx.doi.org/10.1016/j.molcel.2010.09.027 Molecular Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier Open Archive |
| spellingShingle | Leung, Anthony Sharp, Phillip A. MicroRNA Functions in Stress Responses |
| title | MicroRNA Functions in Stress Responses |
| title_full | MicroRNA Functions in Stress Responses |
| title_fullStr | MicroRNA Functions in Stress Responses |
| title_full_unstemmed | MicroRNA Functions in Stress Responses |
| title_short | MicroRNA Functions in Stress Responses |
| title_sort | microrna functions in stress responses |
| url | http://hdl.handle.net/1721.1/85552 https://orcid.org/0000-0003-1465-1691 |
| work_keys_str_mv | AT leunganthony micrornafunctionsinstressresponses AT sharpphillipa micrornafunctionsinstressresponses |