Understanding Metabolic Regulation and Its Influence on Cell Physiology
Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased expo- nentially. Combined with these insights, advances in analytical methods for quantifying met...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2014
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| Online Access: | http://hdl.handle.net/1721.1/85553 https://orcid.org/0000-0002-6702-4192 |
| _version_ | 1811093431091462144 |
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| author | Metallo, Christian M. Vander Heiden, Matthew G. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Metallo, Christian M. Vander Heiden, Matthew G. |
| author_sort | Metallo, Christian M. |
| collection | MIT |
| description | Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased expo- nentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology. |
| first_indexed | 2024-09-23T15:44:56Z |
| format | Article |
| id | mit-1721.1/85553 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:44:56Z |
| publishDate | 2014 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/855532022-10-02T03:50:04Z Understanding Metabolic Regulation and Its Influence on Cell Physiology Metallo, Christian M. Vander Heiden, Matthew G. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Vander Heiden, Matthew G. Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased expo- nentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology. American Cancer Society (Institutional Research Grant 70-002) Burroughs Wellcome Fund Damon Runyon Cancer Research Foundation Smith Family Foundation National Cancer Institute (U.S.) 2014-03-06T21:15:30Z 2014-03-06T21:15:30Z 2013-02 Article http://purl.org/eprint/type/JournalArticle 10972765 http://hdl.handle.net/1721.1/85553 Metallo, Christian M. and Matthew G. Vander Heiden (2013). "Understanding Metabolic Regulation and Its Influence on Cell Physiology." Molecular Cell 49(3): 388-398. https://orcid.org/0000-0002-6702-4192 en_US http://dx.doi.org/10.1016/j.molcel.2013.01.018 Molecular Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier Open Archive |
| spellingShingle | Metallo, Christian M. Vander Heiden, Matthew G. Understanding Metabolic Regulation and Its Influence on Cell Physiology |
| title | Understanding Metabolic Regulation and Its Influence on Cell Physiology |
| title_full | Understanding Metabolic Regulation and Its Influence on Cell Physiology |
| title_fullStr | Understanding Metabolic Regulation and Its Influence on Cell Physiology |
| title_full_unstemmed | Understanding Metabolic Regulation and Its Influence on Cell Physiology |
| title_short | Understanding Metabolic Regulation and Its Influence on Cell Physiology |
| title_sort | understanding metabolic regulation and its influence on cell physiology |
| url | http://hdl.handle.net/1721.1/85553 https://orcid.org/0000-0002-6702-4192 |
| work_keys_str_mv | AT metallochristianm understandingmetabolicregulationanditsinfluenceoncellphysiology AT vanderheidenmatthewg understandingmetabolicregulationanditsinfluenceoncellphysiology |