Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies

Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies

Although numerous mouse models of B-cell malignancy have been developed via the enforced expression of defined oncogenic lesions, the feasibility of generating lineage-defined human B-cell malignancies using mice reconstituted with modified human hematopoietic stem cells (HSCs) remains unclear. In f...

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Bibliographic Details
Main Authors: Schweighofer, C. D., Abruzzo, L., Frenzel, Lukas P., Wendtner, C. M., Leskov, Ilya B., Pallasch, Christian, Drake, Adam, Iliopoulou, Bettina P., Souza, A., Shen, C.-H., Hemann, Michael, Chen, Jianzhu
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/85587
https://orcid.org/0000-0002-5687-6154

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