Role of adult neurogenesis in hippocampal-cortical memory consolidation
Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred...
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| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2014
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| Online Access: | http://hdl.handle.net/1721.1/85595 |
| _version_ | 1826206234819166208 |
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| author | Kitamura, Takashi Inokuchi, Kaoru |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kitamura, Takashi Inokuchi, Kaoru |
| author_sort | Kitamura, Takashi |
| collection | MIT |
| description | Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision. |
| first_indexed | 2024-09-23T13:26:13Z |
| format | Article |
| id | mit-1721.1/85595 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:26:13Z |
| publishDate | 2014 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/855952022-10-01T15:15:30Z Role of adult neurogenesis in hippocampal-cortical memory consolidation Kitamura, Takashi Inokuchi, Kaoru Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Kitamura, Takashi Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision. 2014-03-10T19:45:06Z 2014-03-10T19:45:06Z 2014-02 2013-11 2014-03-05T12:38:45Z Article http://purl.org/eprint/type/JournalArticle 1756-6606 http://hdl.handle.net/1721.1/85595 Kitamura, Takashi, and Kaoru Inokuchi. “Role of Adult Neurogenesis in Hippocampal-Cortical Memory Consolidation.” Molecular Brain 7.1 (2014): 13. en http://dx.doi.org/10.1186/1756-6606-7-13 Molecular Brain Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Takashi Kitamura et al.; licensee BioMed Central Ltd. application/pdf BioMed Central Ltd BioMed Central Ltd |
| spellingShingle | Kitamura, Takashi Inokuchi, Kaoru Role of adult neurogenesis in hippocampal-cortical memory consolidation |
| title | Role of adult neurogenesis in hippocampal-cortical memory consolidation |
| title_full | Role of adult neurogenesis in hippocampal-cortical memory consolidation |
| title_fullStr | Role of adult neurogenesis in hippocampal-cortical memory consolidation |
| title_full_unstemmed | Role of adult neurogenesis in hippocampal-cortical memory consolidation |
| title_short | Role of adult neurogenesis in hippocampal-cortical memory consolidation |
| title_sort | role of adult neurogenesis in hippocampal cortical memory consolidation |
| url | http://hdl.handle.net/1721.1/85595 |
| work_keys_str_mv | AT kitamuratakashi roleofadultneurogenesisinhippocampalcorticalmemoryconsolidation AT inokuchikaoru roleofadultneurogenesisinhippocampalcorticalmemoryconsolidation |