Induction and molecular signature of pathogenic T[subscript H]17 cells
Interleukin 17 (IL-17)-producing helper T cells (T[subscript H]17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T[subscript H]17 cells are main drivers of autoimmune tissue injury. However, not all T[subscript H]17 cells are...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/85641 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826189106117345280 |
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| author | Lee, Youjin Awasthi, Amit Yosef, Nir Quintana, Francisco J. Xiao, Sheng Peters, Anneli Wu, Chuan Kleinewietfeld, Markus Kunder, Sharon Hafler, David A. Sobel, Raymond A. Regev, Aviv Kuchroo, Vijay K. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lee, Youjin Awasthi, Amit Yosef, Nir Quintana, Francisco J. Xiao, Sheng Peters, Anneli Wu, Chuan Kleinewietfeld, Markus Kunder, Sharon Hafler, David A. Sobel, Raymond A. Regev, Aviv Kuchroo, Vijay K. |
| author_sort | Lee, Youjin |
| collection | MIT |
| description | Interleukin 17 (IL-17)-producing helper T cells (T[subscript H]17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T[subscript H]17 cells are main drivers of autoimmune tissue injury. However, not all T[subscript H]17 cells are pathogenic; in fact, T[subscript H]17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of TGF-β3 by developing T[subscript H]17 cells was dependent on IL-23, which together with IL-6 induced very pathogenic T[subscript H]17 cells. Moreover, TGF-β3-induced T[subscript H]17 cells were functionally and molecularly distinct from TGF-β1-induced T[subscript H]17 cells and had a molecular signature that defined pathogenic effector T[subscript H]17 cells in autoimmune disease. |
| first_indexed | 2024-09-23T08:09:37Z |
| format | Article |
| id | mit-1721.1/85641 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:09:37Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/856412022-09-30T07:58:24Z Induction and molecular signature of pathogenic T[subscript H]17 cells Lee, Youjin Awasthi, Amit Yosef, Nir Quintana, Francisco J. Xiao, Sheng Peters, Anneli Wu, Chuan Kleinewietfeld, Markus Kunder, Sharon Hafler, David A. Sobel, Raymond A. Regev, Aviv Kuchroo, Vijay K. Massachusetts Institute of Technology. Department of Biology Regev, Aviv Interleukin 17 (IL-17)-producing helper T cells (T[subscript H]17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T[subscript H]17 cells are main drivers of autoimmune tissue injury. However, not all T[subscript H]17 cells are pathogenic; in fact, T[subscript H]17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of TGF-β3 by developing T[subscript H]17 cells was dependent on IL-23, which together with IL-6 induced very pathogenic T[subscript H]17 cells. Moreover, TGF-β3-induced T[subscript H]17 cells were functionally and molecularly distinct from TGF-β1-induced T[subscript H]17 cells and had a molecular signature that defined pathogenic effector T[subscript H]17 cells in autoimmune disease. National Institutes of Health (U.S.) (1P01HG005062-01) National Institutes of Health (U.S.) (DP1-OD003958-01) Merkin Family Foundation for Stem Cell Research National Human Genome Research Institute (U.S.) Howard Hughes Medical Institute 2014-03-14T17:59:42Z 2014-03-14T17:59:42Z 2012-09 2012-04 Article http://purl.org/eprint/type/JournalArticle 1529-2908 1529-2916 http://hdl.handle.net/1721.1/85641 Lee, Youjin, Amit Awasthi, Nir Yosef, Francisco J Quintana, Sheng Xiao, Anneli Peters, Chuan Wu, et al. “Induction and molecular signature of pathogenic TH17 cells.” Nature Immunology 13, no. 10 (September 9, 2012): 991-999. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1038/ni.2416 Nature Immunology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Lee, Youjin Awasthi, Amit Yosef, Nir Quintana, Francisco J. Xiao, Sheng Peters, Anneli Wu, Chuan Kleinewietfeld, Markus Kunder, Sharon Hafler, David A. Sobel, Raymond A. Regev, Aviv Kuchroo, Vijay K. Induction and molecular signature of pathogenic T[subscript H]17 cells |
| title | Induction and molecular signature of pathogenic T[subscript H]17 cells |
| title_full | Induction and molecular signature of pathogenic T[subscript H]17 cells |
| title_fullStr | Induction and molecular signature of pathogenic T[subscript H]17 cells |
| title_full_unstemmed | Induction and molecular signature of pathogenic T[subscript H]17 cells |
| title_short | Induction and molecular signature of pathogenic T[subscript H]17 cells |
| title_sort | induction and molecular signature of pathogenic t subscript h 17 cells |
| url | http://hdl.handle.net/1721.1/85641 https://orcid.org/0000-0001-8567-2049 |
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