Aneuploidy: implications for protein homeostasis and disease
It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation. Here, we summarize new findings...
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| Format: | Article |
| Language: | en_US |
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Company of Biologists
2014
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| Online Access: | http://hdl.handle.net/1721.1/85675 https://orcid.org/0000-0001-9837-0314 |
| _version_ | 1811077234443681792 |
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| author | Oromendia, Ana Belen Amon, Angelika B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Oromendia, Ana Belen Amon, Angelika B |
| author_sort | Oromendia, Ana Belen |
| collection | MIT |
| description | It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation. Here, we summarize new findings characterizing the impact of aneuploidy on protein quality control. Because aneuploidy has been associated with many diseases, foremost among them being cancer, and has also been linked to aging, we also offer our perspective on whether and how the effects of aneuploidy on protein quality control could contribute to these conditions. We argue that acquiring a deeper understanding of the relationship between aneuploidy, disease and aging could lead to the development of new anti-cancer and anti-aging treatments. |
| first_indexed | 2024-09-23T10:39:47Z |
| format | Article |
| id | mit-1721.1/85675 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:39:47Z |
| publishDate | 2014 |
| publisher | Company of Biologists |
| record_format | dspace |
| spelling | mit-1721.1/856752022-09-27T14:04:21Z Aneuploidy: implications for protein homeostasis and disease Oromendia, Ana Belen Amon, Angelika B Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Oromendia, Ana Belen Amon, Angelika B. It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation. Here, we summarize new findings characterizing the impact of aneuploidy on protein quality control. Because aneuploidy has been associated with many diseases, foremost among them being cancer, and has also been linked to aging, we also offer our perspective on whether and how the effects of aneuploidy on protein quality control could contribute to these conditions. We argue that acquiring a deeper understanding of the relationship between aneuploidy, disease and aging could lead to the development of new anti-cancer and anti-aging treatments. 2014-03-17T16:25:55Z 2014-03-17T16:25:55Z 2014-01 Article http://purl.org/eprint/type/JournalArticle 1754-8403 1754-8411 http://hdl.handle.net/1721.1/85675 Oromendia, A. B., and A. Amon. “Aneuploidy: Implications for Protein Homeostasis and Disease.” Disease Models & Mechanisms 7, no. 1 (January 1, 2014): 15–20. https://orcid.org/0000-0001-9837-0314 en_US http://dx.doi.org/10.1242/dmm.013391 Disease Models & Mechanisms Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/ application/pdf Company of Biologists Company of Biologists |
| spellingShingle | Oromendia, Ana Belen Amon, Angelika B Aneuploidy: implications for protein homeostasis and disease |
| title | Aneuploidy: implications for protein homeostasis and disease |
| title_full | Aneuploidy: implications for protein homeostasis and disease |
| title_fullStr | Aneuploidy: implications for protein homeostasis and disease |
| title_full_unstemmed | Aneuploidy: implications for protein homeostasis and disease |
| title_short | Aneuploidy: implications for protein homeostasis and disease |
| title_sort | aneuploidy implications for protein homeostasis and disease |
| url | http://hdl.handle.net/1721.1/85675 https://orcid.org/0000-0001-9837-0314 |
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