Molecular definition of the identity and activation of natural killer cells
available in PMC 2013 April 01.
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
2014
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| Online Access: | http://hdl.handle.net/1721.1/85836 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826210510297628672 |
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| author | Bezman, Natalie A. Kim, Charles C. Sun, Joseph C. Min-Oo, Gundula Hendricks, Deborah W. Kamimura, Yosuke Best, J. Adam Goldrath, Ananda W. Lanier, Lewis L. Regev, Aviv Immunological Genome Project Consortium |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bezman, Natalie A. Kim, Charles C. Sun, Joseph C. Min-Oo, Gundula Hendricks, Deborah W. Kamimura, Yosuke Best, J. Adam Goldrath, Ananda W. Lanier, Lewis L. Regev, Aviv Immunological Genome Project Consortium |
| author_sort | Bezman, Natalie A. |
| collection | MIT |
| description | available in PMC 2013 April 01. |
| first_indexed | 2024-09-23T14:51:06Z |
| format | Article |
| id | mit-1721.1/85836 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:51:06Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | mit-1721.1/858362022-09-29T10:57:05Z Molecular definition of the identity and activation of natural killer cells Bezman, Natalie A. Kim, Charles C. Sun, Joseph C. Min-Oo, Gundula Hendricks, Deborah W. Kamimura, Yosuke Best, J. Adam Goldrath, Ananda W. Lanier, Lewis L. Regev, Aviv Immunological Genome Project Consortium Massachusetts Institute of Technology. Department of Biology Regev, Aviv available in PMC 2013 April 01. Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8+ T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states. National Institute of Allergy and Infectious Diseases (U.S.) (NIH (R24 AI072073)) National Institute of Allergy and Infectious Diseases (U.S.) (NIH (R01 AI068129)) National Institute of Allergy and Infectious Diseases (U.S.) (NIH (T32AI060537)) National Institute of Allergy and Infectious Diseases (U.S.) (NIH (AI072117)) Canadian Institutes of Health Research American Cancer Society Searle Scholars Program 2014-03-19T19:21:08Z 2014-03-19T19:21:08Z 2012-08 2012-04 Article http://purl.org/eprint/type/JournalArticle 1529-2908 1529-2916 http://hdl.handle.net/1721.1/85836 Bezman, Natalie A, Charles C Kim, Joseph C Sun, Gundula Min-Oo, Deborah W Hendricks, Yosuke Kamimura, J Adam Best, et al. “Molecular definition of the identity and activation of natural killer cells.” Nature Immunology 13, no. 10 (August 19, 2012): 1000-1009. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1038/ni.2395 Nature Immunology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf PMC |
| spellingShingle | Bezman, Natalie A. Kim, Charles C. Sun, Joseph C. Min-Oo, Gundula Hendricks, Deborah W. Kamimura, Yosuke Best, J. Adam Goldrath, Ananda W. Lanier, Lewis L. Regev, Aviv Immunological Genome Project Consortium Molecular definition of the identity and activation of natural killer cells |
| title | Molecular definition of the identity and activation of natural killer cells |
| title_full | Molecular definition of the identity and activation of natural killer cells |
| title_fullStr | Molecular definition of the identity and activation of natural killer cells |
| title_full_unstemmed | Molecular definition of the identity and activation of natural killer cells |
| title_short | Molecular definition of the identity and activation of natural killer cells |
| title_sort | molecular definition of the identity and activation of natural killer cells |
| url | http://hdl.handle.net/1721.1/85836 https://orcid.org/0000-0001-8567-2049 |
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