Genetics of germ cell development
The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, Drosophila melanogaster and the mouse display striking similarities, as well as...
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/85857 https://orcid.org/0000-0001-9920-3411 |
| _version_ | 1826212566458695680 |
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| author | Lesch, Bluma J. Page, David C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lesch, Bluma J. Page, David C |
| author_sort | Lesch, Bluma J. |
| collection | MIT |
| description | The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, Drosophila melanogaster and the mouse display striking similarities, as well as major differences, in the means by which they control germ cell development. Recent developments in genetic technologies allow a more detailed comparison of the germ cells of these three organisms than has previously been possible, shedding light not only on universal aspects of germline regulation, but also on the control of the pluripotent state in vivo and on the earliest steps of embryogenesis. Here, we highlight themes from the comparison of these three alternative strategies for navigating the fundamental cycle of sexual reproduction. |
| first_indexed | 2024-09-23T15:25:28Z |
| format | Article |
| id | mit-1721.1/85857 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:25:28Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/858572022-09-29T14:38:43Z Genetics of germ cell development Lesch, Bluma J. Page, David C Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Page, David C. Page, David C. The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, Drosophila melanogaster and the mouse display striking similarities, as well as major differences, in the means by which they control germ cell development. Recent developments in genetic technologies allow a more detailed comparison of the germ cells of these three organisms than has previously been possible, shedding light not only on universal aspects of germline regulation, but also on the control of the pluripotent state in vivo and on the earliest steps of embryogenesis. Here, we highlight themes from the comparison of these three alternative strategies for navigating the fundamental cycle of sexual reproduction. Howard Hughes Medical Institute (Investigator) 2014-03-20T20:29:39Z 2014-03-20T20:29:39Z 2012-10 Article http://purl.org/eprint/type/JournalArticle 1471-0056 1471-0064 http://hdl.handle.net/1721.1/85857 Lesch, Bluma J., and David C. Page. “Genetics of Germ Cell Development.” Nature Reviews Genetics 13, no. 11 (October 9, 2012): 781–794. https://orcid.org/0000-0001-9920-3411 en_US http://dx.doi.org/10.1038/nrg3294 Nature Reviews Genetics Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group Page via Courtney Crummett |
| spellingShingle | Lesch, Bluma J. Page, David C Genetics of germ cell development |
| title | Genetics of germ cell development |
| title_full | Genetics of germ cell development |
| title_fullStr | Genetics of germ cell development |
| title_full_unstemmed | Genetics of germ cell development |
| title_short | Genetics of germ cell development |
| title_sort | genetics of germ cell development |
| url | http://hdl.handle.net/1721.1/85857 https://orcid.org/0000-0001-9920-3411 |
| work_keys_str_mv | AT leschblumaj geneticsofgermcelldevelopment AT pagedavidc geneticsofgermcelldevelopment |