Targeting H3K4 trimethylation in Huntington disease

Targeting H3K4 trimethylation in Huntington disease

Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a chromatin signature for this mark....

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Bibliographic Details
Main Authors:	Ng, Christopher W., Yildirim, Ferah, Labadorf, Adam, Fraenkel, Ernest, Vashishtha, Malini, Kratter, Ian H., Bodai, Laszlo, Song, Wan, Lau, Alice L., Vogel-Ciernia, Annie, Troncosco, Juan, Ross, Christopher A., Bates, Gillian P., Krainc, Dimitri, Sadri-Vakili, Ghazaleh, Finkbeiner, Steven, Marsh, J. Lawrence, Thompson, Leslie M., Wasylenko, Theresa Anne, Housman, David E
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Language:	en_US
Published:	National Academy of Sciences (U.S.) 2014
Online Access:	http://hdl.handle.net/1721.1/85912 https://orcid.org/0000-0002-0524-5301 https://orcid.org/0000-0003-1381-4313 https://orcid.org/0000-0001-9249-8181 https://orcid.org/0000-0001-5016-0756

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