Island Cells Control Temporal Association Memory
Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2014
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| Online Access: | http://hdl.handle.net/1721.1/85965 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826203470591426560 |
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| author | Kitamura, Takashi Suh, Junghyup Kohara, Keigo Tonegawa, Susumu Yoshiki, Atsushi Abe, Kuniya Pignatelli di Spinazzola, Michele |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kitamura, Takashi Suh, Junghyup Kohara, Keigo Tonegawa, Susumu Yoshiki, Atsushi Abe, Kuniya Pignatelli di Spinazzola, Michele |
| author_sort | Kitamura, Takashi |
| collection | MIT |
| description | Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory. |
| first_indexed | 2024-09-23T12:37:34Z |
| format | Article |
| id | mit-1721.1/85965 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:37:34Z |
| publishDate | 2014 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/859652022-10-01T10:06:27Z Island Cells Control Temporal Association Memory Kitamura, Takashi Suh, Junghyup Kohara, Keigo Tonegawa, Susumu Yoshiki, Atsushi Abe, Kuniya Pignatelli di Spinazzola, Michele Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Tonegawa, Susumu Kitamura, Takashi Pignatelli di Spinazzola, Mich Suh, Junghyup Kohara, Keigo Tonegawa, Susumu Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) to the hippocampal CA1 region. However, the identification of neural circuits that regulate this association has remained unknown. In layer II of entorhinal cortex (ECII), we report clusters of excitatory neurons called island cells, which appear in a curvilinear matrix of bulblike structures, directly project to CA1, and activate interneurons that target the distal dendrites of CA1 pyramidal neurons. Island cells suppress the excitatory MECIII input through the feed-forward inhibition to control the strength and duration of temporal association in trace fear memory. Together, the two EC inputs compose a control circuit for temporal association memory. RIKEN Brain Science Institute 2014-03-28T18:20:55Z 2014-03-28T18:20:55Z 2014-01 2013-08 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/85965 Kitamura, T., M. Pignatelli, J. Suh, K. Kohara, A. Yoshiki, K. Abe, and S. Tonegawa. “Island Cells Control Temporal Association Memory.” Science 343, no. 6173 (February 21, 2014): 896–901. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1126/science.1244634 Science Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) Tonegawa via Courtney Crummett |
| spellingShingle | Kitamura, Takashi Suh, Junghyup Kohara, Keigo Tonegawa, Susumu Yoshiki, Atsushi Abe, Kuniya Pignatelli di Spinazzola, Michele Island Cells Control Temporal Association Memory |
| title | Island Cells Control Temporal Association Memory |
| title_full | Island Cells Control Temporal Association Memory |
| title_fullStr | Island Cells Control Temporal Association Memory |
| title_full_unstemmed | Island Cells Control Temporal Association Memory |
| title_short | Island Cells Control Temporal Association Memory |
| title_sort | island cells control temporal association memory |
| url | http://hdl.handle.net/1721.1/85965 https://orcid.org/0000-0003-2839-8228 |
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