Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography
We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantif...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2014
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| Online Access: | http://hdl.handle.net/1721.1/86018 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826202862009450496 |
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| author | Wei, Eric Jia, Yali Tan, Ou Fujimoto, James G. Huang, David Potsaid, Benjamin M. Liu, Jonathan Jaoshin Choi, Woo Jhon |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Wei, Eric Jia, Yali Tan, Ou Fujimoto, James G. Huang, David Potsaid, Benjamin M. Liu, Jonathan Jaoshin Choi, Woo Jhon |
| author_sort | Wei, Eric |
| collection | MIT |
| description | We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantify blood flow as measured with parafoveal flow index (PFI), which is proportional to the density of blood vessels and the velocity of blood flow in the parafoveal region of the macula. PFI measurements were taken in 15 second intervals during a 4 minute period consisting of 1 minute of baseline, 2 minutes with an 8 Hz reversing checkerboard pattern stimulation, and 1 minute without stimulation. PFI measurements increased 6.1±4.7% (p = .001) during the first minute of stimulation, with the most significant increase in PFI occurring 30 seconds into stimulation (p<0.001). These results suggest that pattern stimulation induces a change to retinal blood flow that can be reliably measured with OCT angiography. |
| first_indexed | 2024-09-23T12:21:33Z |
| format | Article |
| id | mit-1721.1/86018 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:21:33Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
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| spelling | mit-1721.1/860182022-09-28T07:51:35Z Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography Wei, Eric Jia, Yali Tan, Ou Fujimoto, James G. Huang, David Potsaid, Benjamin M. Liu, Jonathan Jaoshin Choi, Woo Jhon Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Potsaid, Benjamin M. Liu, Jonathan Jaoshin Choi, Woo Jhon Fujimoto, James G. We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantify blood flow as measured with parafoveal flow index (PFI), which is proportional to the density of blood vessels and the velocity of blood flow in the parafoveal region of the macula. PFI measurements were taken in 15 second intervals during a 4 minute period consisting of 1 minute of baseline, 2 minutes with an 8 Hz reversing checkerboard pattern stimulation, and 1 minute without stimulation. PFI measurements increased 6.1±4.7% (p = .001) during the first minute of stimulation, with the most significant increase in PFI occurring 30 seconds into stimulation (p<0.001). These results suggest that pattern stimulation induces a change to retinal blood flow that can be reliably measured with OCT angiography. National Institutes of Health (U.S.) (Grant R01 EY013516) National Institutes of Health (U.S.) (Grant Rosenbaum's P30EY010572) Research to Prevent Blindness, Inc. (United States) (Grant R01-Ey11289-26) United States. Air Force Office of Scientific Research (FA9550-10-1-0551) 2014-04-04T14:45:24Z 2014-04-04T14:45:24Z 2013-12 2013-05 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/86018 Wei, Eric, Yali Jia, Ou Tan, Benjamin Potsaid, Jonathan J. Liu, WooJhon Choi, James G. Fujimoto, and David Huang. “Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography.” Edited by Samuel G. Solomon. PLoS ONE 8, no. 12 (December 2, 2013): e81343. https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1371/journal.pone.0081343 PLoS ONE Publisher with Creative Commons License http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science PLoS |
| spellingShingle | Wei, Eric Jia, Yali Tan, Ou Fujimoto, James G. Huang, David Potsaid, Benjamin M. Liu, Jonathan Jaoshin Choi, Woo Jhon Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography |
| title | Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography |
| title_full | Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography |
| title_fullStr | Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography |
| title_full_unstemmed | Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography |
| title_short | Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography |
| title_sort | parafoveal retinal vascular response to pattern visual stimulation assessed with oct angiography |
| url | http://hdl.handle.net/1721.1/86018 https://orcid.org/0000-0002-0828-4357 |
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