Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity
Signal transduction proteins are often multi-domain proteins that arose through the fusion of previously independent proteins. How such a change in the spatial arrangement of proteins impacts their evolution and the selective pressures acting on individual residues is largely unknown. We explored th...
| Main Authors: | , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell
2014
|
| Online Access: | http://hdl.handle.net/1721.1/86127 https://orcid.org/0000-0002-8288-7607 |