A biomechanical investigation of the structure--function relationships in the human tongue
Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2001.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2005
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| Online Access: | http://hdl.handle.net/1721.1/8628 |
| _version_ | 1826188899031973888 |
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| author | Napadow, Vitaly J., 1971- |
| author2 | Richard J. Gilbert. |
| author_facet | Richard J. Gilbert. Napadow, Vitaly J., 1971- |
| author_sort | Napadow, Vitaly J., 1971- |
| collection | MIT |
| description | Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2001. |
| first_indexed | 2024-09-23T08:06:45Z |
| format | Thesis |
| id | mit-1721.1/8628 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T08:06:45Z |
| publishDate | 2005 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/86282022-01-13T07:53:45Z A biomechanical investigation of the structure--function relationships in the human tongue Napadow, Vitaly J., 1971- Richard J. Gilbert. Harvard University--MIT Division of Health Sciences and Technology. Harvard University--MIT Division of Health Sciences and Technology Harvard University--MIT Division of Health Sciences and Technology. Thesis (Ph. D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 2001. Includes bibliographical references (p. 147-154). The human tongue is a versatile, lithe and structurally complex muscular organ that is of paramount importance for many physiological tasks. The lingual musculature is composed of various orthogonally oriented myofiber populations. Furthermore, coupling this knowledge of tissue myoarchitecture with patterns of regional deformation offers the ability to explore complex structure-function relationships in the organ. Tongue myoarchitecture was studied with Diffusion Tensor MRI (DTI), which derived the spatial diffusion tensor field in the tongue. Since, diffusivity relates directly to myofiber orientation, this in vivo technique successfully produced a virtual anatomical atlas. In order to relate this 3D myoarchitecture to physiological deformations, in vivo strain was quantified by an MRI tagging technique. This technique tagged lingual tissue with a rectilinear grid, which was subsequently imaged to track and quantify deformation through 3D strain measures. Anterior protrusion, sagittal bending, and oral stage deglutition were studied with this technique. The results demonstrated that synergistic co-contraction between various muscle populations produced the necessary deformations in global tongue shape. In order to delineate specific muscular contributions to sagittal bending, the tongue was modeled by a thermal bimetal strip analog wherein thermal contraction approximated muscle fiber activation. (cont.) The results confirmed our hypothesis that sagittal bending resulted from synergistic co-contraction of two distinct myofiber populations. In conclusion, tongue deformation is intimately related to the lingual musculature, and our results confirm the characterization of the tongue as a muscular hydrostat - an organ whose musculature produces deformation as well as the structural support for that deformation. by Vitaly J. Napadow. Ph.D. 2005-08-23T21:50:38Z 2005-08-23T21:50:38Z 2001 2001 Thesis http://hdl.handle.net/1721.1/8628 49544689 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 148 p. 13414225 bytes 13413981 bytes application/pdf application/pdf application/pdf Massachusetts Institute of Technology |
| spellingShingle | Harvard University--MIT Division of Health Sciences and Technology. Napadow, Vitaly J., 1971- A biomechanical investigation of the structure--function relationships in the human tongue |
| title | A biomechanical investigation of the structure--function relationships in the human tongue |
| title_full | A biomechanical investigation of the structure--function relationships in the human tongue |
| title_fullStr | A biomechanical investigation of the structure--function relationships in the human tongue |
| title_full_unstemmed | A biomechanical investigation of the structure--function relationships in the human tongue |
| title_short | A biomechanical investigation of the structure--function relationships in the human tongue |
| title_sort | biomechanical investigation of the structure function relationships in the human tongue |
| topic | Harvard University--MIT Division of Health Sciences and Technology. |
| url | http://hdl.handle.net/1721.1/8628 |
| work_keys_str_mv | AT napadowvitalyj1971 abiomechanicalinvestigationofthestructurefunctionrelationshipsinthehumantongue AT napadowvitalyj1971 biomechanicalinvestigationofthestructurefunctionrelationshipsinthehumantongue |