Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation
After infection, many factors coordinate the population expansion and differentiation of CD8[superscript +] effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8[superscript +] T cell transcriptome throughout infection to establish...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/86359 https://orcid.org/0000-0001-8567-2049 |
| _version_ | 1826217616002252800 |
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| author | Regev, Aviv Best, J. Adam Blair, David A. Knell, Jamie Yang, Edward Mayya, Viveka Doedens, Andrew Dustin, Michael L. Goldrath, Ananda W. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Regev, Aviv Best, J. Adam Blair, David A. Knell, Jamie Yang, Edward Mayya, Viveka Doedens, Andrew Dustin, Michael L. Goldrath, Ananda W. |
| author_sort | Regev, Aviv |
| collection | MIT |
| description | After infection, many factors coordinate the population expansion and differentiation of CD8[superscript +] effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8[superscript +] T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8[superscript +] effector cells. Long-lived memory CD8[superscript +] cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8[superscript +] effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8[superscript +] T cell immunity. |
| first_indexed | 2024-09-23T17:06:30Z |
| format | Article |
| id | mit-1721.1/86359 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:06:30Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/863592022-10-03T10:26:33Z Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation Regev, Aviv Best, J. Adam Blair, David A. Knell, Jamie Yang, Edward Mayya, Viveka Doedens, Andrew Dustin, Michael L. Goldrath, Ananda W. Massachusetts Institute of Technology. Department of Biology Regev, Aviv After infection, many factors coordinate the population expansion and differentiation of CD8[superscript +] effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8[superscript +] T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8[superscript +] effector cells. Long-lived memory CD8[superscript +] cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8[superscript +] effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8[superscript +] T cell immunity. National Institutes of Health (U.S.) (P30 CA016087) National Institute of Allergy and Infectious Diseases (U.S.) (R24 AI072073) 2014-05-02T14:25:14Z 2014-05-02T14:25:14Z 2013-02 2012-08 Article http://purl.org/eprint/type/JournalArticle 1529-2908 1529-2916 http://hdl.handle.net/1721.1/86359 Best, J Adam, David A Blair, Jamie Knell, Edward Yang, Viveka Mayya, Andrew Doedens, Michael L Dustin, et al. “Transcriptional Insights into the CD8+ T Cell Response to Infection and Memory T Cell Formation.” Nature Immunology 14, no. 4 (February 10, 2013): 404–412. https://orcid.org/0000-0001-8567-2049 en_US http://dx.doi.org/10.1038/ni.2536 Nature Immunology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Regev, Aviv Best, J. Adam Blair, David A. Knell, Jamie Yang, Edward Mayya, Viveka Doedens, Andrew Dustin, Michael L. Goldrath, Ananda W. Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation |
| title | Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation |
| title_full | Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation |
| title_fullStr | Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation |
| title_full_unstemmed | Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation |
| title_short | Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation |
| title_sort | transcriptional insights into the cd8 superscript t cell response to infection and memory t cell formation |
| url | http://hdl.handle.net/1721.1/86359 https://orcid.org/0000-0001-8567-2049 |
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