4D dynamic imaging of the eye using ultrahigh speed SS-OCT
Recent advances in swept-source / Fourier domain optical coherence tomography (SS-OCT) technology enable in vivo ultrahigh speed imaging, offering a promising technique for four-dimensional (4-D) imaging of the eye. Using an ultrahigh speed tunable vertical cavity surface emitting laser (VCSEL) ligh...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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SPIE
2014
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| Online Access: | http://hdl.handle.net/1721.1/86411 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811096384236945408 |
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| author | Grulkowski, Ireneusz Jayaraman, Vijaysekhar Cable, Alex E. Kraus, Martin Franz Georg Hornegger, Joachim Duker, Jay S. Fujimoto, James G. Liu, Jonathan Jaoshin Potsaid, Benjamin M. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Grulkowski, Ireneusz Jayaraman, Vijaysekhar Cable, Alex E. Kraus, Martin Franz Georg Hornegger, Joachim Duker, Jay S. Fujimoto, James G. Liu, Jonathan Jaoshin Potsaid, Benjamin M. |
| author_sort | Grulkowski, Ireneusz |
| collection | MIT |
| description | Recent advances in swept-source / Fourier domain optical coherence tomography (SS-OCT) technology enable in vivo ultrahigh speed imaging, offering a promising technique for four-dimensional (4-D) imaging of the eye. Using an ultrahigh speed tunable vertical cavity surface emitting laser (VCSEL) light source based SS-OCT prototype system, we performed imaging of human eye dynamics in four different imaging modes: 1) Pupillary reaction to light at 200,000 axial scans per second and 9 μm resolution in tissue. 2) Anterior eye focusing dynamics at 100,000 axial scans per second and 9 μm resolution in tissue. 3) Tear film break up at 50,000 axial scans per second and 19 μm resolution in tissue. 4) Retinal blood flow at 800,000 axial scans per second and 12 μm resolution in tissue. The combination of tunable ultrahigh speeds and long coherence length of the VCSEL along with the outstanding roll-off performance of SS-OCT makes this technology an ideal tool for time-resolved volumetric imaging of the eye. Visualization and quantitative analysis of 4-D OCT data can potentially provide insight to functional and structural changes in the eye during disease progression. Ultrahigh speed imaging using SS-OCT promises to enable novel 4-D visualization of realtime dynamic processes of the human eye. Furthermore, this non-invasive imaging technology is a promising tool for research to characterize and understand a variety of visual functions. |
| first_indexed | 2024-09-23T16:42:53Z |
| format | Article |
| id | mit-1721.1/86411 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:42:53Z |
| publishDate | 2014 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/864112022-10-03T07:44:13Z 4D dynamic imaging of the eye using ultrahigh speed SS-OCT Grulkowski, Ireneusz Jayaraman, Vijaysekhar Cable, Alex E. Kraus, Martin Franz Georg Hornegger, Joachim Duker, Jay S. Fujimoto, James G. Liu, Jonathan Jaoshin Potsaid, Benjamin M. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Liu, Jonathan Jaoshin Grulkowski, Ireneusz Potsaid, Benjamin M. Fujimoto, James G. Recent advances in swept-source / Fourier domain optical coherence tomography (SS-OCT) technology enable in vivo ultrahigh speed imaging, offering a promising technique for four-dimensional (4-D) imaging of the eye. Using an ultrahigh speed tunable vertical cavity surface emitting laser (VCSEL) light source based SS-OCT prototype system, we performed imaging of human eye dynamics in four different imaging modes: 1) Pupillary reaction to light at 200,000 axial scans per second and 9 μm resolution in tissue. 2) Anterior eye focusing dynamics at 100,000 axial scans per second and 9 μm resolution in tissue. 3) Tear film break up at 50,000 axial scans per second and 19 μm resolution in tissue. 4) Retinal blood flow at 800,000 axial scans per second and 12 μm resolution in tissue. The combination of tunable ultrahigh speeds and long coherence length of the VCSEL along with the outstanding roll-off performance of SS-OCT makes this technology an ideal tool for time-resolved volumetric imaging of the eye. Visualization and quantitative analysis of 4-D OCT data can potentially provide insight to functional and structural changes in the eye during disease progression. Ultrahigh speed imaging using SS-OCT promises to enable novel 4-D visualization of realtime dynamic processes of the human eye. Furthermore, this non-invasive imaging technology is a promising tool for research to characterize and understand a variety of visual functions. National Institutes of Health (U.S.) (NIH R01-EY011289-27) National Institutes of Health (U.S.) (R01-EY013178-12) National Institutes of Health (U.S.) (R01-EY013516-09) National Institutes of Health (U.S.) (R01-EY018184-05) National Institutes of Health (U.S.) (R01-EY019029-04) National Institutes of Health (U.S.) (R01-CA075289-14) National Institutes of Health (U.S.) (R01-HL095717-04) National Institutes of Health (U.S.) (R01-NS057476-05) United States. Air Force Office of Scientific Research (AFOSR FA9550-10-1-0063) United States. Dept. of Defense United States. Dept. of Defense. Medical Free Electron Laser Program 2014-05-05T18:00:50Z 2014-05-05T18:00:50Z 2013-03 Article http://purl.org/eprint/type/ConferencePaper 1605-7422 1605-7413 http://hdl.handle.net/1721.1/86411 Liu, Jonathan J., Ireneusz Grulkowski, Benjamin Potsaid, Vijaysekhar Jayaraman, Alex E. Cable, Martin F. Kraus, Joachim Hornegger, Jay S. Duker, and James G. Fujimoto. “4D Dynamic Imaging of the Eye Using Ultrahigh Speed SS-OCT.” Edited by Fabrice Manns, Per G. Söderberg, and Arthur Ho. Ophthalmic Technologies XXIII (March 26, 2013). © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE) https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1117/12.2004369 Proceedings of SPIE--the International Society for Optical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Grulkowski, Ireneusz Jayaraman, Vijaysekhar Cable, Alex E. Kraus, Martin Franz Georg Hornegger, Joachim Duker, Jay S. Fujimoto, James G. Liu, Jonathan Jaoshin Potsaid, Benjamin M. 4D dynamic imaging of the eye using ultrahigh speed SS-OCT |
| title | 4D dynamic imaging of the eye using ultrahigh speed SS-OCT |
| title_full | 4D dynamic imaging of the eye using ultrahigh speed SS-OCT |
| title_fullStr | 4D dynamic imaging of the eye using ultrahigh speed SS-OCT |
| title_full_unstemmed | 4D dynamic imaging of the eye using ultrahigh speed SS-OCT |
| title_short | 4D dynamic imaging of the eye using ultrahigh speed SS-OCT |
| title_sort | 4d dynamic imaging of the eye using ultrahigh speed ss oct |
| url | http://hdl.handle.net/1721.1/86411 https://orcid.org/0000-0002-0828-4357 |
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