The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long noncoding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 or...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/87007 |
| _version_ | 1811069145657114624 |
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| author | Grote, Phillip Wittler, Lars Hendrix, David A. Koch, Frederic Beisaw, Arica Macura, Karol Kellis, Manolis Werber, Martin Herrmann, Bernhard G. Wahrisch, Sandra Blass, Gaby |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Grote, Phillip Wittler, Lars Hendrix, David A. Koch, Frederic Beisaw, Arica Macura, Karol Kellis, Manolis Werber, Martin Herrmann, Bernhard G. Wahrisch, Sandra Blass, Gaby |
| author_sort | Grote, Phillip |
| collection | MIT |
| description | The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long noncoding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 or TrxG/MLL activity. Here we show that the lateral mesoderm-specific lncRNA Fendrr is essential for proper heart and body wall development in the mouse. Embryos lacking Fendrr displayed upregulation of several transcription factors controlling lateral plate or cardiac mesoderm differentiation, accompanied by a drastic reduction in PRC2 occupancy along with decreased H3K27 trimethylation and/or an increase in H3K4 trimethylation at their promoters. Fendrr binds to both the PRC2 and TrxG/MLL complexes, suggesting that it acts as modulator of chromatin signatures that define gene activity. Thus, we identified an lncRNA that plays an essential role in the regulatory networks controlling the fate of lateral mesoderm derivatives. |
| first_indexed | 2024-09-23T08:06:26Z |
| format | Article |
| id | mit-1721.1/87007 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:06:26Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/870072022-09-23T10:56:37Z The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse Grote, Phillip Wittler, Lars Hendrix, David A. Koch, Frederic Beisaw, Arica Macura, Karol Kellis, Manolis Werber, Martin Herrmann, Bernhard G. Wahrisch, Sandra Blass, Gaby Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Hendrix, David A. Kellis, Manolis The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long noncoding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 or TrxG/MLL activity. Here we show that the lateral mesoderm-specific lncRNA Fendrr is essential for proper heart and body wall development in the mouse. Embryos lacking Fendrr displayed upregulation of several transcription factors controlling lateral plate or cardiac mesoderm differentiation, accompanied by a drastic reduction in PRC2 occupancy along with decreased H3K27 trimethylation and/or an increase in H3K4 trimethylation at their promoters. Fendrr binds to both the PRC2 and TrxG/MLL complexes, suggesting that it acts as modulator of chromatin signatures that define gene activity. Thus, we identified an lncRNA that plays an essential role in the regulatory networks controlling the fate of lateral mesoderm derivatives. 2014-05-15T18:21:49Z 2014-05-15T18:21:49Z 2013-01 2012-12 Article http://purl.org/eprint/type/JournalArticle 15345807 1878-1551 http://hdl.handle.net/1721.1/87007 Grote, Phillip, Lars Wittler, David Hendrix, Frederic Koch, Sandra Wahrisch, Arica Beisaw, Karol Macura, et al. “The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse.” Developmental Cell 24, no. 2 (January 2013): 206–214. © 2013 Elsevier Inc. en_US http://dx.doi.org/10.1016/j.devcel.2012.12.012 Developmental Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier Open Archive |
| spellingShingle | Grote, Phillip Wittler, Lars Hendrix, David A. Koch, Frederic Beisaw, Arica Macura, Karol Kellis, Manolis Werber, Martin Herrmann, Bernhard G. Wahrisch, Sandra Blass, Gaby The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse |
| title | The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse |
| title_full | The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse |
| title_fullStr | The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse |
| title_full_unstemmed | The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse |
| title_short | The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse |
| title_sort | tissue specific lncrna fendrr is an essential regulator of heart and body wall development in the mouse |
| url | http://hdl.handle.net/1721.1/87007 |
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