Cochlear neuropathy and the coding of supra-threshold sound
Many listeners with hearing thresholds within the clinically normal range nonetheless complain of difficulty hearing in everyday settings and understanding speech in noise. Converging evidence from human and animal studies points to one potential source of such difficulties: differences in the fidel...
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| Format: | Article |
| Language: | en_US |
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Frontiers Research Foundation
2014
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| Online Access: | http://hdl.handle.net/1721.1/87579 https://orcid.org/0000-0002-9144-6010 |
| _version_ | 1826201715116867584 |
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| author | Bharadwaj, Hari M. Verhulst, Sarah Liberman, M. Charles Shinn-Cunningham, Barbara G. Shaheen, Luke Abraham |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Bharadwaj, Hari M. Verhulst, Sarah Liberman, M. Charles Shinn-Cunningham, Barbara G. Shaheen, Luke Abraham |
| author_sort | Bharadwaj, Hari M. |
| collection | MIT |
| description | Many listeners with hearing thresholds within the clinically normal range nonetheless complain of difficulty hearing in everyday settings and understanding speech in noise. Converging evidence from human and animal studies points to one potential source of such difficulties: differences in the fidelity with which supra-threshold sound is encoded in the early portions of the auditory pathway. Measures of auditory subcortical steady-state responses (SSSRs) in humans and animals support the idea that the temporal precision of the early auditory representation can be poor even when hearing thresholds are normal. In humans with normal hearing thresholds (NHTs), paradigms that require listeners to make use of the detailed spectro-temporal structure of supra-threshold sound, such as selective attention and discrimination of frequency modulation (FM), reveal individual differences that correlate with subcortical temporal coding precision. Animal studies show that noise exposure and aging can cause a loss of a large percentage of auditory nerve fibers (ANFs) without any significant change in measured audiograms. Here, we argue that cochlear neuropathy may reduce encoding precision of supra-threshold sound, and that this manifests both behaviorally and in SSSRs in humans. Furthermore, recent studies suggest that noise-induced neuropathy may be selective for higher-threshold, lower-spontaneous-rate nerve fibers. Based on our hypothesis, we suggest some approaches that may yield particularly sensitive, objective measures of supra-threshold coding deficits that arise due to neuropathy. Finally, we comment on the potential clinical significance of these ideas and identify areas for future investigation. |
| first_indexed | 2024-09-23T11:55:36Z |
| format | Article |
| id | mit-1721.1/87579 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:55:36Z |
| publishDate | 2014 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/875792022-10-01T07:00:54Z Cochlear neuropathy and the coding of supra-threshold sound Bharadwaj, Hari M. Verhulst, Sarah Liberman, M. Charles Shinn-Cunningham, Barbara G. Shaheen, Luke Abraham Harvard University--MIT Division of Health Sciences and Technology Shaheen, Luke Abraham Liberman, M. Charles Many listeners with hearing thresholds within the clinically normal range nonetheless complain of difficulty hearing in everyday settings and understanding speech in noise. Converging evidence from human and animal studies points to one potential source of such difficulties: differences in the fidelity with which supra-threshold sound is encoded in the early portions of the auditory pathway. Measures of auditory subcortical steady-state responses (SSSRs) in humans and animals support the idea that the temporal precision of the early auditory representation can be poor even when hearing thresholds are normal. In humans with normal hearing thresholds (NHTs), paradigms that require listeners to make use of the detailed spectro-temporal structure of supra-threshold sound, such as selective attention and discrimination of frequency modulation (FM), reveal individual differences that correlate with subcortical temporal coding precision. Animal studies show that noise exposure and aging can cause a loss of a large percentage of auditory nerve fibers (ANFs) without any significant change in measured audiograms. Here, we argue that cochlear neuropathy may reduce encoding precision of supra-threshold sound, and that this manifests both behaviorally and in SSSRs in humans. Furthermore, recent studies suggest that noise-induced neuropathy may be selective for higher-threshold, lower-spontaneous-rate nerve fibers. Based on our hypothesis, we suggest some approaches that may yield particularly sensitive, objective measures of supra-threshold coding deficits that arise due to neuropathy. Finally, we comment on the potential clinical significance of these ideas and identify areas for future investigation. 2014-05-29T19:42:22Z 2014-05-29T19:42:22Z 2014-02 2013-09 Article http://purl.org/eprint/type/JournalArticle 1662-5137 http://hdl.handle.net/1721.1/87579 Bharadwaj, Hari M., Sarah Verhulst, Luke Shaheen, M. Charles Liberman, and Barbara G. Shinn-Cunningham. “Cochlear Neuropathy and the Coding of Supra-Threshold Sound.” Front. Syst. Neurosci. 8 (2014). https://orcid.org/0000-0002-9144-6010 en_US http://dx.doi.org/10.3389/fnsys.2014.00026 Frontiers in Systems Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Frontiers Research Foundation Frontiers Research Foundation |
| spellingShingle | Bharadwaj, Hari M. Verhulst, Sarah Liberman, M. Charles Shinn-Cunningham, Barbara G. Shaheen, Luke Abraham Cochlear neuropathy and the coding of supra-threshold sound |
| title | Cochlear neuropathy and the coding of supra-threshold sound |
| title_full | Cochlear neuropathy and the coding of supra-threshold sound |
| title_fullStr | Cochlear neuropathy and the coding of supra-threshold sound |
| title_full_unstemmed | Cochlear neuropathy and the coding of supra-threshold sound |
| title_short | Cochlear neuropathy and the coding of supra-threshold sound |
| title_sort | cochlear neuropathy and the coding of supra threshold sound |
| url | http://hdl.handle.net/1721.1/87579 https://orcid.org/0000-0002-9144-6010 |
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