Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer
Near-infrared measurements of glucose in human plasma are performed using a custom, rapid, high-throughput filter-based spectrometer covering a spectral range between 2080 and 2315 nm. Quality of the measured glucose signals is quantified through the use of two figures of merit: selectivity and limi...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
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SPIE
2014
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| Online Access: | http://hdl.handle.net/1721.1/87652 |
| _version_ | 1811084596265091072 |
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| author | Saptari, Vidi Youcef-Toumi, Kamal |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Saptari, Vidi Youcef-Toumi, Kamal |
| author_sort | Saptari, Vidi |
| collection | MIT |
| description | Near-infrared measurements of glucose in human plasma are performed using a custom, rapid, high-throughput filter-based spectrometer covering a spectral range between 2080 and 2315 nm. Quality of the measured glucose signals is quantified through the use of two figures of merit: selectivity and limit of detection. Selectivity measures the uniqueness of the glucose spectrum from among the interfering spectra. Limit of detection measures the smallest glucose concentration change detectable. The proposed system, which includes the spectroscopic hardware and a spectral preprocessing algorithm, is shown to produce a selectivity value of 0.57, with zero being nonselective and one being fully selective, and a limit of detection value of 2.2 mM. Prediction of an independent dataset is also performed using net analyte signal-based and partial least-squares multivariate calibration techniques, which produce standard error of prediction values of 1.14 and 1.45 mM, respectively. |
| first_indexed | 2024-09-23T12:53:40Z |
| format | Article |
| id | mit-1721.1/87652 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:53:40Z |
| publishDate | 2014 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/876522022-09-28T10:43:31Z Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer Saptari, Vidi Youcef-Toumi, Kamal Massachusetts Institute of Technology. Department of Mechanical Engineering Youcef-Toumi, Kamal Near-infrared measurements of glucose in human plasma are performed using a custom, rapid, high-throughput filter-based spectrometer covering a spectral range between 2080 and 2315 nm. Quality of the measured glucose signals is quantified through the use of two figures of merit: selectivity and limit of detection. Selectivity measures the uniqueness of the glucose spectrum from among the interfering spectra. Limit of detection measures the smallest glucose concentration change detectable. The proposed system, which includes the spectroscopic hardware and a spectral preprocessing algorithm, is shown to produce a selectivity value of 0.57, with zero being nonselective and one being fully selective, and a limit of detection value of 2.2 mM. Prediction of an independent dataset is also performed using net analyte signal-based and partial least-squares multivariate calibration techniques, which produce standard error of prediction values of 1.14 and 1.45 mM, respectively. 2014-06-05T16:10:22Z 2014-06-05T16:10:22Z 2005-12 2005-06 Article http://purl.org/eprint/type/JournalArticle 10833668 1560-2281 http://hdl.handle.net/1721.1/87652 Saptari, Vidi, and Kamal Youcef-Toumi. “Measurements and Quality Assessments of Near-Infrared Plasma Glucose Spectra in the Combination Band Region Using a Scanning Filter Spectrometer.” Journal of Biomedical Optics 10, no. 6 (2005): 064039. © 2005 Society of Photo-Optical Instrumentation Engineers en_US http://dx.doi.org/10.1117/1.2141934 Journal of Biomedical Optics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Saptari, Vidi Youcef-Toumi, Kamal Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| title | Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| title_full | Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| title_fullStr | Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| title_full_unstemmed | Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| title_short | Measurements and quality assessments of near-infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| title_sort | measurements and quality assessments of near infrared plasma glucose spectra in the combination band region using a scanning filter spectrometer |
| url | http://hdl.handle.net/1721.1/87652 |
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