Can Financial Engineering Cure Cancer?

Traditional financing sources such as private and public equity may not be ideal for investment projects with low probabilities of success, long time horizons, and large capital requirements. Nevertheless, such projects, if not too highly correlated, may yield attractive risk-adjusted returns when c...

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Bibliographic Details
Main Authors: Fernandez, Jose-Maria, Fagnan, David Erik, Lo, Andrew W., Stein, Roger Mark
Other Authors: Massachusetts Institute of Technology. Operations Research Center
Format: Article
Language:en_US
Published: American Economic Association 2014
Online Access:http://hdl.handle.net/1721.1/87773
https://orcid.org/0000-0003-2944-7773
Description
Summary:Traditional financing sources such as private and public equity may not be ideal for investment projects with low probabilities of success, long time horizons, and large capital requirements. Nevertheless, such projects, if not too highly correlated, may yield attractive risk-adjusted returns when combined into a single portfolio. Such "megafund" portfolios may be too large to finance through private or public equity alone. But with sufficient diversification and risk analytics, debt financing via securitization may be feasible. Credit enhancements (i.e., derivatives and government guarantees) can also improve megafund economics. We present an analytical framework and illustrative empirical examples involving cancer research.