Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography
Objectives: To examine the feasibility of automatically segmented choroidal vessels in three-dimensional (3D) 1060-nmOCT by testing repeatability in healthy and AMD eyes and by mapping Haller's and Sattler's layer thickness in healthy eyes Methods: Fifty-five eyes (from 45 healthy subje...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Public Library of Science
2014
|
| Online Access: | http://hdl.handle.net/1721.1/88042 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826188015509176320 |
|---|---|
| author | Esmaeelpour, Marieh Kajic, Vedran Zabihian, Behrooz Othara, Richu Ansari-Shahrezaei, Siamak Kellner, Lukas Krebs, Ilse Nemetz, Susanne Kraus, Martin Franz Georg Hornegger, Joachim Fujimoto, James G. Drexler, Wolfgang Binder, Susanne |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Esmaeelpour, Marieh Kajic, Vedran Zabihian, Behrooz Othara, Richu Ansari-Shahrezaei, Siamak Kellner, Lukas Krebs, Ilse Nemetz, Susanne Kraus, Martin Franz Georg Hornegger, Joachim Fujimoto, James G. Drexler, Wolfgang Binder, Susanne |
| author_sort | Esmaeelpour, Marieh |
| collection | MIT |
| description | Objectives:
To examine the feasibility of automatically segmented choroidal vessels in three-dimensional (3D) 1060-nmOCT by testing repeatability in healthy and AMD eyes and by mapping Haller's and Sattler's layer thickness in healthy eyes
Methods:
Fifty-five eyes (from 45 healthy subjects and 10 with non-neovascular age-related macular degeneration (AMD) subjects) were imaged by 3D-1060-nmOCT over a 36°x36° field of view. Haller's and Sattler's layer were automatically segmented, mapped and averaged across the Early Treatment Diabetic Retinopathy Study grid. For ten AMD eyes and ten healthy eyes, imaging was repeated within the same session and on another day. Outcomes were the repeatability agreement of Haller's and Sattler's layer thicknesses in healthy and AMD eyes, the validation with ICGA and the statistical analysis of the effect of age and axial eye length (AL) on both healthy choroidalsublayers.
Results:
The coefficients of repeatability for Sattler's and Haller's layers were 35% and 21% in healthy eyes and 44% and 31% in AMD eyes, respectively. The mean±SD healthy central submacular field thickness for Sattler's and Haller's was 87±56 µm and 141±50 µm, respectively, with a significant relationship for AL (P<.001).
Conclusions:
Automated Sattler's and Haller's thickness segmentation generates rapid 3D measurements with a repeatability correspondingto reported manual segmentation. Sublayers in healthy eyes thinnedsignificantly with increasing AL. In the presence of the thinned Sattler's layer in AMD, careful measurement interpretation is needed. Automatic choroidal vascular layer mapping may help to explain if pathological choroidal thinning affects medium and large choroidal vasculature in addition to choriocapillaris loss. |
| first_indexed | 2024-09-23T07:53:18Z |
| format | Article |
| id | mit-1721.1/88042 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T07:53:18Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/880422022-09-23T09:22:40Z Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography Esmaeelpour, Marieh Kajic, Vedran Zabihian, Behrooz Othara, Richu Ansari-Shahrezaei, Siamak Kellner, Lukas Krebs, Ilse Nemetz, Susanne Kraus, Martin Franz Georg Hornegger, Joachim Fujimoto, James G. Drexler, Wolfgang Binder, Susanne Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Fujimoto, James G. Objectives: To examine the feasibility of automatically segmented choroidal vessels in three-dimensional (3D) 1060-nmOCT by testing repeatability in healthy and AMD eyes and by mapping Haller's and Sattler's layer thickness in healthy eyes Methods: Fifty-five eyes (from 45 healthy subjects and 10 with non-neovascular age-related macular degeneration (AMD) subjects) were imaged by 3D-1060-nmOCT over a 36°x36° field of view. Haller's and Sattler's layer were automatically segmented, mapped and averaged across the Early Treatment Diabetic Retinopathy Study grid. For ten AMD eyes and ten healthy eyes, imaging was repeated within the same session and on another day. Outcomes were the repeatability agreement of Haller's and Sattler's layer thicknesses in healthy and AMD eyes, the validation with ICGA and the statistical analysis of the effect of age and axial eye length (AL) on both healthy choroidalsublayers. Results: The coefficients of repeatability for Sattler's and Haller's layers were 35% and 21% in healthy eyes and 44% and 31% in AMD eyes, respectively. The mean±SD healthy central submacular field thickness for Sattler's and Haller's was 87±56 µm and 141±50 µm, respectively, with a significant relationship for AL (P<.001). Conclusions: Automated Sattler's and Haller's thickness segmentation generates rapid 3D measurements with a repeatability correspondingto reported manual segmentation. Sublayers in healthy eyes thinnedsignificantly with increasing AL. In the presence of the thinned Sattler's layer in AMD, careful measurement interpretation is needed. Automatic choroidal vascular layer mapping may help to explain if pathological choroidal thinning affects medium and large choroidal vasculature in addition to choriocapillaris loss. Macular Vision Research Foundation Medical University of Vienna European Union (project FUN OCT (FP7 HEALTH, contract no. 201880)) European Union (FAMOS (FP7 ICT 317744)) European Union (FWF-NFN ‘Photoacoustic imaging in biology and Medicine’, Oesterreichische Nationalbank Jubilaumsfonds projekt (14294)) National Institutes of Health (U.S.) (NIH R01-EY011289-27) Deutsche Forschungsgemeinschaft (DFG-GSC80-SAOT) Deutsche Forschungsgemeinschaft (DFG-GSC80-SAOT, DFG-HO-1791/11-1) Carl Zeiss Meditec, Inc. FEMTOLASERS (Firm) Christian Doppler Society 2014-06-20T14:20:34Z 2014-06-20T14:20:34Z 2014-06 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/88042 Esmaeelpour, Marieh, Vedran Kajic, Behrooz Zabihian, Richu Othara, Siamak Ansari-Shahrezaei, Lukas Kellner, Ilse Krebs, et al. “Choroidal Haller’s and Sattler’s Layer Thickness Measurement Using 3-Dimensional 1060-Nm Optical Coherence Tomography.” Edited by Zsolt Ablonczy. PLoS ONE 9, no. 6 (June 9, 2014): e99690. https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1371/journal.pone.0099690 PLoS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science Public Library of Science |
| spellingShingle | Esmaeelpour, Marieh Kajic, Vedran Zabihian, Behrooz Othara, Richu Ansari-Shahrezaei, Siamak Kellner, Lukas Krebs, Ilse Nemetz, Susanne Kraus, Martin Franz Georg Hornegger, Joachim Fujimoto, James G. Drexler, Wolfgang Binder, Susanne Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography |
| title | Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography |
| title_full | Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography |
| title_fullStr | Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography |
| title_full_unstemmed | Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography |
| title_short | Choroidal Haller's and Sattler's Layer Thickness Measurement Using 3-Dimensional 1060-nm Optical Coherence Tomography |
| title_sort | choroidal haller s and sattler s layer thickness measurement using 3 dimensional 1060 nm optical coherence tomography |
| url | http://hdl.handle.net/1721.1/88042 https://orcid.org/0000-0002-0828-4357 |
| work_keys_str_mv | AT esmaeelpourmarieh choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT kajicvedran choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT zabihianbehrooz choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT othararichu choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT ansarishahrezaeisiamak choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT kellnerlukas choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT krebsilse choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT nemetzsusanne choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT krausmartinfranzgeorg choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT horneggerjoachim choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT fujimotojamesg choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT drexlerwolfgang choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography AT bindersusanne choroidalhallersandsattlerslayerthicknessmeasurementusing3dimensional1060nmopticalcoherencetomography |