Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies
We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks,...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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MDPI AG
2014
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| Online Access: | http://hdl.handle.net/1721.1/88047 https://orcid.org/0000-0002-5224-7764 |
| _version_ | 1811093280734052352 |
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| author | New, Roger Bansal, Gurpal Bogus, Michael Zajkowska, Kasia Rickelt, Steffen Toth, Istvan |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT New, Roger Bansal, Gurpal Bogus, Michael Zajkowska, Kasia Rickelt, Steffen Toth, Istvan |
| author_sort | New, Roger |
| collection | MIT |
| description | We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner. |
| first_indexed | 2024-09-23T15:42:45Z |
| format | Article |
| id | mit-1721.1/88047 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:42:45Z |
| publishDate | 2014 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/880472022-09-29T15:39:11Z Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies New, Roger Bansal, Gurpal Bogus, Michael Zajkowska, Kasia Rickelt, Steffen Toth, Istvan Koch Institute for Integrative Cancer Research at MIT Rickelt, Steffen We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner. 2014-06-20T15:16:04Z 2014-06-20T15:16:04Z 2013-03 2013-03 Article http://purl.org/eprint/type/JournalArticle 1420-3049 http://hdl.handle.net/1721.1/88047 New, Roger, Gurpal Bansal, Michael Bogus, Kasia Zajkowska, Steffen Rickelt, and Istvan Toth. “Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies.” Molecules 18, no. 3 (March 14, 2013): 3427–3441. https://orcid.org/0000-0002-5224-7764 en_US http://dx.doi.org/10.3390/molecules18033427 Molecules Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/ application/pdf MDPI AG MDPI Publishing |
| spellingShingle | New, Roger Bansal, Gurpal Bogus, Michael Zajkowska, Kasia Rickelt, Steffen Toth, Istvan Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies |
| title | Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies |
| title_full | Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies |
| title_fullStr | Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies |
| title_full_unstemmed | Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies |
| title_short | Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies |
| title_sort | use of mixed micelles for presentation of building blocks in a new combinatorial discovery methodology proof of concept studies |
| url | http://hdl.handle.net/1721.1/88047 https://orcid.org/0000-0002-5224-7764 |
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