Microscale Strategies for Generating Cell-Encapsulating Hydrogels
Hydrogels in which cells are encapsulated are of great potential interest for tissue engineering applications. These gels provide a structure inside which cells can spread and proliferate. Such structures benefit from controlled microarchitectures that can affect the behavior of the enclosed cells....
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
MDPI AG
2014
|
| Online Access: | http://hdl.handle.net/1721.1/88052 |
| _version_ | 1811075740791209984 |
|---|---|
| author | Selimović, Šeila Oh, Jonghyun Bae, Hojae Dokmeci, Mehmet Khademhosseini, Ali |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Selimović, Šeila Oh, Jonghyun Bae, Hojae Dokmeci, Mehmet Khademhosseini, Ali |
| author_sort | Selimović, Šeila |
| collection | MIT |
| description | Hydrogels in which cells are encapsulated are of great potential interest for tissue engineering applications. These gels provide a structure inside which cells can spread and proliferate. Such structures benefit from controlled microarchitectures that can affect the behavior of the enclosed cells. Microfabrication-based techniques are emerging as powerful approaches to generate such cell-encapsulating hydrogel structures. In this paper we introduce common hydrogels and their crosslinking methods and review the latest microscale approaches for generation of cell containing gel particles. We specifically focus on microfluidics-based methods and on techniques such as micromolding and electrospinning. |
| first_indexed | 2024-09-23T10:11:08Z |
| format | Article |
| id | mit-1721.1/88052 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:11:08Z |
| publishDate | 2014 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/880522022-09-30T19:27:38Z Microscale Strategies for Generating Cell-Encapsulating Hydrogels Selimović, Šeila Oh, Jonghyun Bae, Hojae Dokmeci, Mehmet Khademhosseini, Ali Harvard University--MIT Division of Health Sciences and Technology Dokmeci, Mehmet Khademhosseini, Ali Selimović, Šeila Oh, Jonghyun Hydrogels in which cells are encapsulated are of great potential interest for tissue engineering applications. These gels provide a structure inside which cells can spread and proliferate. Such structures benefit from controlled microarchitectures that can affect the behavior of the enclosed cells. Microfabrication-based techniques are emerging as powerful approaches to generate such cell-encapsulating hydrogel structures. In this paper we introduce common hydrogels and their crosslinking methods and review the latest microscale approaches for generation of cell containing gel particles. We specifically focus on microfluidics-based methods and on techniques such as micromolding and electrospinning. National Science Foundation (U.S.) (DMR0847287) National Institutes of Health (U.S.) (EB008392) National Institutes of Health (U.S.) (DE019024) National Institutes of Health (U.S.) (HL099073) National Institutes of Health (U.S.) (AR057837) National Institutes of Health (U.S.) (HL092836) United States. Army Research Office (contract W911NF-07-D-0004) United States. Army Research Office (Institute for Soldier Nanotechnology) United States. Army. Corps of Engineers Innovative Med Tech (Postdoctoral fellowship) 2014-06-20T17:17:42Z 2014-06-20T17:17:42Z 2012-09 2012-07 Article http://purl.org/eprint/type/JournalArticle 2073-4360 http://hdl.handle.net/1721.1/88052 Selimović, Šeila, Jonghyun Oh, Hojae Bae, Mehmet Dokmeci, and Ali Khademhosseini. “Microscale Strategies for Generating Cell-Encapsulating Hydrogels.” Polymers 4, no. 4 (September 5, 2012): 1554–1579. en_US http://dx.doi.org/10.3390/polym4031554 Polymers Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/ application/pdf MDPI AG MDPI Publishing |
| spellingShingle | Selimović, Šeila Oh, Jonghyun Bae, Hojae Dokmeci, Mehmet Khademhosseini, Ali Microscale Strategies for Generating Cell-Encapsulating Hydrogels |
| title | Microscale Strategies for Generating Cell-Encapsulating Hydrogels |
| title_full | Microscale Strategies for Generating Cell-Encapsulating Hydrogels |
| title_fullStr | Microscale Strategies for Generating Cell-Encapsulating Hydrogels |
| title_full_unstemmed | Microscale Strategies for Generating Cell-Encapsulating Hydrogels |
| title_short | Microscale Strategies for Generating Cell-Encapsulating Hydrogels |
| title_sort | microscale strategies for generating cell encapsulating hydrogels |
| url | http://hdl.handle.net/1721.1/88052 |
| work_keys_str_mv | AT selimovicseila microscalestrategiesforgeneratingcellencapsulatinghydrogels AT ohjonghyun microscalestrategiesforgeneratingcellencapsulatinghydrogels AT baehojae microscalestrategiesforgeneratingcellencapsulatinghydrogels AT dokmecimehmet microscalestrategiesforgeneratingcellencapsulatinghydrogels AT khademhosseiniali microscalestrategiesforgeneratingcellencapsulatinghydrogels |