The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders
MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence br...
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| Format: | Article |
| Language: | en_US |
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Frontiers Research Foundation
2014
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| Online Access: | http://hdl.handle.net/1721.1/88062 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1826211389825351680 |
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| author | Mellios, Nikolaos Sur, Mriganka |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Mellios, Nikolaos Sur, Mriganka |
| author_sort | Mellios, Nikolaos |
| collection | MIT |
| description | MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence brain plasticity, their relevance for neuropsychiatric diseases with known deficits in synaptic plasticity, such as schizophrenia and autism, has not been adequately explored. In this review we discuss the intersection between current and old knowledge on the role of miRNAs in brain plasticity and function with a focus in the potential involvement of brain expressed miRNAs in the pathophysiology of neuropsychiatric disorders. |
| first_indexed | 2024-09-23T15:05:08Z |
| format | Article |
| id | mit-1721.1/88062 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:05:08Z |
| publishDate | 2014 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/880622022-10-02T00:28:28Z The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders Mellios, Nikolaos Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Mellios, Nikolaos Sur, Mriganka MicroRNAs (miRNAs) are small non-coding RNAs conserved throughout evolution whose perceived importance for brain development and maturation is increasingly being understood. Although a plethora of new discoveries have provided novel insights into miRNA-mediated molecular mechanisms that influence brain plasticity, their relevance for neuropsychiatric diseases with known deficits in synaptic plasticity, such as schizophrenia and autism, has not been adequately explored. In this review we discuss the intersection between current and old knowledge on the role of miRNAs in brain plasticity and function with a focus in the potential involvement of brain expressed miRNAs in the pathophysiology of neuropsychiatric disorders. 2014-06-23T16:02:37Z 2014-06-23T16:02:37Z 2012-04 Article http://purl.org/eprint/type/JournalArticle 1664-0640 http://hdl.handle.net/1721.1/88062 Mellios, Nikolaos, and Mriganka Sur. “The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders.” Frontiers in Psychiatry 3 (2012). https://orcid.org/0000-0003-2442-5671 en_US http://dx.doi.org/10.3389/fpsyt.2012.00039 Frontiers in Psychiatry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Frontiers Research Foundation Frontiers Research Foundation |
| spellingShingle | Mellios, Nikolaos Sur, Mriganka The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
| title | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
| title_full | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
| title_fullStr | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
| title_full_unstemmed | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
| title_short | The Emerging Role of microRNAs in Schizophrenia and Autism Spectrum Disorders |
| title_sort | emerging role of micrornas in schizophrenia and autism spectrum disorders |
| url | http://hdl.handle.net/1721.1/88062 https://orcid.org/0000-0003-2442-5671 |
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