Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder
Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied m...
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Frontiers Research Foundation
2014
|
| Online Access: | http://hdl.handle.net/1721.1/88101 https://orcid.org/0000-0002-4676-4554 |
| _version_ | 1811072843851497472 |
|---|---|
| author | Dauvermann, Maria R. Whalley, Heather C. Schmidt, Andre Lee, Graham Romaniuk, Liana Roberts, Neil Johnstone, Eve C. Lawrie, Stephen M. Moorhead, Thomas W. J. |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Dauvermann, Maria R. Whalley, Heather C. Schmidt, Andre Lee, Graham Romaniuk, Liana Roberts, Neil Johnstone, Eve C. Lawrie, Stephen M. Moorhead, Thomas W. J. |
| author_sort | Dauvermann, Maria R. |
| collection | MIT |
| description | Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia. |
| first_indexed | 2024-09-23T09:16:35Z |
| format | Article |
| id | mit-1721.1/88101 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:16:35Z |
| publishDate | 2014 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/881012022-09-30T14:08:17Z Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder Dauvermann, Maria R. Whalley, Heather C. Schmidt, Andre Lee, Graham Romaniuk, Liana Roberts, Neil Johnstone, Eve C. Lawrie, Stephen M. Moorhead, Thomas W. J. McGovern Institute for Brain Research at MIT Lee, Graham Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia. Dr. Mortimer and Theresa Sackler Foundation Royal Society (Great Britain) (Dorothy Hodgkin Fellowship) 2014-06-24T20:30:02Z 2014-06-24T20:30:02Z 2014-03 2013-09 Article http://purl.org/eprint/type/JournalArticle 1664-0640 http://hdl.handle.net/1721.1/88101 Dauvermann, Maria R., Heather C. Whalley, André Schmidt, Graham L. Lee, Liana Romaniuk, Neil Roberts, Eve C. Johnstone, Stephen M. Lawrie, and Thomas W. J. Moorhead. “Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder.” Frontiers in Psychiatry 5 (March 25, 2014). https://orcid.org/0000-0002-4676-4554 en_US http://dx.doi.org/10.3389/fpsyt.2014.00030 Frontiers in Psychiatry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Frontiers Research Foundation Frontiers Research Foundation |
| spellingShingle | Dauvermann, Maria R. Whalley, Heather C. Schmidt, Andre Lee, Graham Romaniuk, Liana Roberts, Neil Johnstone, Eve C. Lawrie, Stephen M. Moorhead, Thomas W. J. Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder |
| title | Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder |
| title_full | Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder |
| title_fullStr | Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder |
| title_full_unstemmed | Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder |
| title_short | Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder |
| title_sort | computational neuropsychiatry schizophrenia as a cognitive brain network disorder |
| url | http://hdl.handle.net/1721.1/88101 https://orcid.org/0000-0002-4676-4554 |
| work_keys_str_mv | AT dauvermannmariar computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT whalleyheatherc computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT schmidtandre computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT leegraham computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT romaniukliana computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT robertsneil computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT johnstoneevec computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT lawriestephenm computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder AT moorheadthomaswj computationalneuropsychiatryschizophreniaasacognitivebrainnetworkdisorder |