Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury

Histone Acetylation and CREB Binding Protein Are Required for Neuronal Resistance against Ischemic Injury

Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating that the outcome of cerebral ischemia depends crucially on the acetylation s...

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Bibliographic Details
Main Authors: Yildirim, Ferah, Ji, Shengbo, Kronenberg, Golo, Barco, Angel, Olivares, Roman, Benito, Eva, Dirnagl, Ulrich, Gertz, Karen, Endres, Matthias, Harms, Christoph, Meisel, Andreas
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/88169

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