Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

Performance-enhanced mesenchymal stem cells via intracellular delivery of steroids

Inadequate immunomodulatory potency of mesenchymal stem cells (MSC) may limit their therapeutic efficacy. We report glucocorticoid steroids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of MSC immunomodulatory function. This effect depends on signaling...

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Bibliographic Details
Main Authors: Ankrum, James Allen, Dastidar, Riddhi G., Ong, Joon Faii, Levy, Oren, Karp, Jeffrey Michael
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/88230
https://orcid.org/0000-0003-3959-6158

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