Triggered optical coherence tomography for capturing rapid periodic motion
Quantitative cross-sectional imaging of vocal folds during phonation is potentially useful for diagnosis and treatments of laryngeal disorders. Optical coherence tomography (OCT) is a powerful technique, but its relatively low frame rates makes it challenging to visualize rapidly vibrating tissues....
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/88238 |
| _version_ | 1826200784804511744 |
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| author | Chang, Ernest W. Kobler, James B. Yun, Seok Hyun (Andy) |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Chang, Ernest W. Kobler, James B. Yun, Seok Hyun (Andy) |
| author_sort | Chang, Ernest W. |
| collection | MIT |
| description | Quantitative cross-sectional imaging of vocal folds during phonation is potentially useful for diagnosis and treatments of laryngeal disorders. Optical coherence tomography (OCT) is a powerful technique, but its relatively low frame rates makes it challenging to visualize rapidly vibrating tissues. Here, we demonstrate a novel method based on triggered laser scanning to capture 4-dimensional (4D) images of samples in motu at audio frequencies over 100 Hz. As proof-of-concept experiments, we applied this technique to imaging the oscillations of biopolymer gels on acoustic vibrators and aerodynamically driven vibrations of the vocal fold in an ex vivo calf larynx model. Our results suggest that triggered 4D OCT may be useful in understanding and assessing the function of vocal folds and developing novel treatments in research and clinical settings. |
| first_indexed | 2024-09-23T11:41:42Z |
| format | Article |
| id | mit-1721.1/88238 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:41:42Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/882382022-09-27T21:17:20Z Triggered optical coherence tomography for capturing rapid periodic motion Chang, Ernest W. Kobler, James B. Yun, Seok Hyun (Andy) Harvard University--MIT Division of Health Sciences and Technology Yun, Seok Hyun (Andy) Quantitative cross-sectional imaging of vocal folds during phonation is potentially useful for diagnosis and treatments of laryngeal disorders. Optical coherence tomography (OCT) is a powerful technique, but its relatively low frame rates makes it challenging to visualize rapidly vibrating tissues. Here, we demonstrate a novel method based on triggered laser scanning to capture 4-dimensional (4D) images of samples in motu at audio frequencies over 100 Hz. As proof-of-concept experiments, we applied this technique to imaging the oscillations of biopolymer gels on acoustic vibrators and aerodynamically driven vibrations of the vocal fold in an ex vivo calf larynx model. Our results suggest that triggered 4D OCT may be useful in understanding and assessing the function of vocal folds and developing novel treatments in research and clinical settings. Eugene B. Casey Foundation Wellman Center for Photomedicine (Graduate student fellowship) National Research Foundation of Korea (R31-2008-000-10071-0) National Institutes of Health (U.S.) (P41 RR032042) Center for Integration of Medicine and Innovative Technology (CIMIT) 2014-07-09T18:38:50Z 2014-07-09T18:38:50Z 2011-07 2011-04 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/88238 Chang, Ernest W., James B. Kobler, and Seok H. Yun. “Triggered Optical Coherence Tomography for Capturing Rapid Periodic Motion.” Sci. Rep. 1 (July 28, 2011). en_US http://dx.doi.org/10.1038/srep00048 Scientific Reports Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/3.0/ application/pdf Nature Publishing Group Nature Publishing Group |
| spellingShingle | Chang, Ernest W. Kobler, James B. Yun, Seok Hyun (Andy) Triggered optical coherence tomography for capturing rapid periodic motion |
| title | Triggered optical coherence tomography for capturing rapid periodic motion |
| title_full | Triggered optical coherence tomography for capturing rapid periodic motion |
| title_fullStr | Triggered optical coherence tomography for capturing rapid periodic motion |
| title_full_unstemmed | Triggered optical coherence tomography for capturing rapid periodic motion |
| title_short | Triggered optical coherence tomography for capturing rapid periodic motion |
| title_sort | triggered optical coherence tomography for capturing rapid periodic motion |
| url | http://hdl.handle.net/1721.1/88238 |
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